{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:31:49Z","timestamp":1783791109887,"version":"3.55.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61806159"],"award-info":[{"award-number":["61806159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61902301"],"award-info":[{"award-number":["61902301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Basic Research Program of Shaanxi","award":["2023-JC-YB-558"],"award-info":[{"award-number":["2023-JC-YB-558"]}]},{"name":"Xi\u2019an Science and Technology Bureau Science and Technology Innovation Leading Project","award":["21XJZZ0020"],"award-info":[{"award-number":["21XJZZ0020"]}]},{"name":"Doctoral Scientific Research Foundation of Xi\u2019an Polytechnic University","award":["BS202108"],"award-info":[{"award-number":["BS202108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Cancer is a molecular complex and heterogeneous disease. Each type of cancer is usually composed of several subtypes with different treatment responses and clinical outcomes. Therefore, subtyping is a crucial step in cancer diagnosis and therapy. The rapid advances in high-throughput sequencing technologies provide an increasing amount of multi-omics data, which benefits our understanding of cancer genetic architecture, and yet poses new challenges in multi-omics data integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We propose a graph convolutional network model, called MRGCN for multi-omics data integrative representation. MRGCN simultaneously encodes and reconstructs multiple omics expression and similarity relationships into a shared latent embedding space. In addition, MRGCN adopts an indicator matrix to denote the situation of missing values in partial omics, so that the full and partial multi-omics processing procedures are combined in a unified framework. Experimental results on 11 multi-omics datasets show that cancer subtypes obtained by MRGCN with superior enriched clinical parameters and log-rank test P-values in survival analysis over many typical integrative methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>https:\/\/github.com\/Polytech-bioinf\/MRGCN.git https:\/\/figshare.com\/articles\/software\/MRGCN\/23058503.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad353","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T09:05:04Z","timestamp":1685523904000},"source":"Crossref","is-referenced-by-count":27,"title":["MRGCN: cancer subtyping with multi-reconstruction graph convolutional network using full and partial multi-omics dataset"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-8727","authenticated-orcid":false,"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"The Shaanxi Key Laboratory of Clothing Intelligence, School of Computer Science, Xi\u2019an Polytechnic University , Xi\u2019an 710048, China"},{"name":"Donnelly Centre for Cellular and Biomolecular Research, University of Toronto , Toronto, ON M5S 3E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"The Shaanxi Key Laboratory of Clothing Intelligence, School of Computer Science, Xi\u2019an Polytechnic University , Xi\u2019an 710048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Shaanxi Key Laboratory of Clothing Intelligence, School of Computer Science, Xi\u2019an Polytechnic University , 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