{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:49:41Z","timestamp":1772909381623,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T00:00:00Z","timestamp":1688083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Monarch Initiative"},{"name":"Phenomics First Resource, a Center of Excellence in Genomic Science"},{"name":"National Institute of Health"},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["#1RM1HG010860-01"],"award-info":[{"award-number":["#1RM1HG010860-01"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Knowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of KGs is lacking.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here we present KG-Hub, a platform that enables standardized construction, exchange, and reuse of KGs. Features include a simple, modular extract\u2013transform\u2013load pattern for producing graphs compliant with Biolink Model (a high-level data model for standardizing biological data), easy integration of any OBO (Open Biological and Biomedical Ontologies) ontology, cached downloads of upstream data sources, versioned and automatically updated builds with stable URLs, web-browsable storage of KG artifacts on cloud infrastructure, and easy reuse of transformed subgraphs across projects. Current KG-Hub projects span use cases including COVID-19 research, drug repurposing, microbial\u2013environmental interactions, and rare disease research. KG-Hub is equipped with tooling to easily analyze and manipulate KGs. KG-Hub is also tightly integrated with graph machine learning (ML) tools which allow automated graph ML, including node embeddings and training of models for link prediction and node classification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>https:\/\/kghub.org.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad418","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T13:52:45Z","timestamp":1688133165000},"source":"Crossref","is-referenced-by-count":30,"title":["KG-Hub\u2014building and exchanging biological knowledge graphs"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-7831","authenticated-orcid":false,"given":"J Harry","family":"Caufield","sequence":"first","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"given":"Tim","family":"Putman","sequence":"additional","affiliation":[{"name":"Anschutz Medical Campus, University of Colorado , Aurora, CO 80045, United States"}]},{"given":"Kevin","family":"Schaper","sequence":"additional","affiliation":[{"name":"Anschutz Medical Campus, University of Colorado , Aurora, CO 80045, United States"}]},{"given":"Deepak R","family":"Unni","sequence":"additional","affiliation":[{"name":"SIB Swiss Institute of Bioinformatics , Basel 1015, Switzerland"}]},{"given":"Harshad","family":"Hegde","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"given":"Tiffany J","family":"Callahan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, Columbia University Irving Medical Center , New York, NY 10032, United States"}]},{"given":"Luca","family":"Cappelletti","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Milano , Milan 20126, Italy"}]},{"given":"Sierra A T","family":"Moxon","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"given":"Vida","family":"Ravanmehr","sequence":"additional","affiliation":[{"name":"Department of Lymphoma-Myeloma, MD Anderson Cancer Center , Houston, TX 77030, United States"}]},{"given":"Seth","family":"Carbon","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"given":"Lauren E","family":"Chan","sequence":"additional","affiliation":[{"name":"College of Public Health and Human Sciences, Oregon State University , Corvallis, OR 97331, United 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Italy"}]},{"given":"Nicolas","family":"Matentzoglu","sequence":"additional","affiliation":[{"name":"Semanticly , Athens, Greece"}]},{"given":"Richard M","family":"Bruskiewich","sequence":"additional","affiliation":[{"name":"STAR Informatics, Delphinai Corporation , Sooke, BC V9Z 0M3, Canada"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2908-3327","authenticated-orcid":false,"given":"Anne E","family":"Thessen","sequence":"additional","affiliation":[{"name":"Anschutz Medical Campus, University of Colorado , Aurora, CO 80045, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-3707","authenticated-orcid":false,"given":"Nomi L","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"given":"Monica C","family":"Munoz-Torres","sequence":"additional","affiliation":[{"name":"Anschutz Medical Campus, University of Colorado , Aurora, CO 80045, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9114-8737","authenticated-orcid":false,"given":"Melissa A","family":"Haendel","sequence":"additional","affiliation":[{"name":"Anschutz Medical Campus, University of Colorado , Aurora, CO 80045, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-9199","authenticated-orcid":false,"given":"Peter N","family":"Robinson","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory for Genomic Medicine , Farmington, CT 06032, United States"}]},{"given":"Marcin P","family":"Joachimiak","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory , Berkeley, CA 94720, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-2165","authenticated-orcid":false,"given":"Christopher J","family":"Mungall","sequence":"additional","affiliation":[{"name":"Division of Environmental Genomics and Systems Biology, Lawrence Berkeley 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