{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:04:46Z","timestamp":1775012686208,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72001205"],"award-info":[{"award-number":["72001205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72271237"],"award-info":[{"award-number":["72271237"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Analyzing genetic data to identify markers and construct predictive models is of great interest in biomedical research. However, limited by cost and sample availability, genetic studies often suffer from the \u201csmall sample size, high dimensionality\u201d problem. To tackle this problem, an integrative analysis that collectively analyzes multiple datasets with compatible designs is often conducted. For regularizing estimation and selecting relevant variables, penalization and other regularization techniques are routinely adopted. \u201cBlindly\u201d searching over a vast number of variables may not be efficient.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We propose incorporating prior information to assist integrative analysis of multiple genetic datasets. To obtain accurate prior information, we adopt a convolutional neural network with an active learning strategy to label textual information from previous studies. Then the extracted prior information is incorporated using a group LASSO-based technique. We conducted a series of simulation studies that demonstrated the satisfactory performance of the proposed method. Finally, data on skin cutaneous melanoma are analyzed to establish practical utility.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Code is available at https:\/\/github.com\/ldz7\/PAIA. The data that support the findings in this article are openly available in TCGA (The Cancer Genome Atlas) at https:\/\/portal.gdc.cancer.gov\/.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad452","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T17:28:42Z","timestamp":1690306122000},"source":"Crossref","is-referenced-by-count":8,"title":["Prior information-assisted integrative analysis of multiple datasets"],"prefix":"10.1093","volume":"39","author":[{"given":"Feifei","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Applied Statistics, Renmin University of China , Beijing 100872, China"},{"name":"School of Statistics, Renmin University of China , Beijing 100872, China"},{"name":"Institute for Data Science in Health, Renmin University of China , Beijing 100872, 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