{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:45:30Z","timestamp":1775907930496,"version":"3.50.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Luxembourg National Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>In many high-dimensional prediction or classification tasks, complementary data on the features are available, e.g. prior biological knowledge on (epi)genetic markers. Here we consider tasks with numerical prior information that provide an insight into the importance (weight) and the direction (sign) of the feature effects, e.g. regression coefficients from previous studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We propose an approach for integrating multiple sources of such prior information into penalized regression. If suitable co-data are available, this improves the predictive performance, as shown by simulation and application.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The proposed method is implemented in the R package transreg (https:\/\/github.com\/lcsb-bds\/transreg, https:\/\/cran.r-project.org\/package=transreg).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad680","type":"journal-article","created":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:15:10Z","timestamp":1699748110000},"source":"Crossref","is-referenced-by-count":3,"title":["Penalized regression with multiple sources of prior effects"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-4801","authenticated-orcid":false,"given":"Armin","family":"Rauschenberger","sequence":"first","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-3904","authenticated-orcid":false,"given":"Zied","family":"Landoulsi","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, Luxembourg"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-8472","authenticated-orcid":false,"given":"Mark A","family":"van de Wiel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science (EDS), Amsterdam University Medical Centers (Amsterdam UMC) , 1081 HV Amsterdam, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-7469","authenticated-orcid":false,"given":"Enrico","family":"Glaab","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg , 4362 Esch-sur-Alzette, 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