{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T03:02:24Z","timestamp":1776049344546,"version":"3.50.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Holland Proton Therapy Center","award":["2019020"],"award-info":[{"award-number":["2019020"]}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["U54EY032442"],"award-info":[{"award-number":["U54EY032442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["U54DK134302"],"award-info":[{"award-number":["U54DK134302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK133766"],"award-info":[{"award-number":["U01DK133766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG078803"],"award-info":[{"award-number":["R01AG078803"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL screening, yet existing methods are vulnerable to prevalent selection bias in SL data and reliant on cancer or tissue type-specific omics, which can be scarce. Notably, sequence similarity remains underexplored as a proxy for related gene function and joint essentiality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We propose ELISL, Early\u2013Late Integrated SL prediction with forest ensembles, using context-free protein sequence embeddings and context-specific omics from cell lines and tissue. Across eight cancer types, ELISL showed superior robustness to selection bias and recovery of known SL genes, as well as promising cross-cancer predictions. Co-occurring mutations in a BRCA gene and ELISL-predicted pairs from the HH, FGF, WNT, or NEIL gene families were associated with longer patient survival times, revealing therapeutic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Data: 10.6084\/m9.figshare.23607558 &amp; Code: github.com\/joanagoncalveslab\/ELISL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btad764","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:37:54Z","timestamp":1702899474000},"source":"Crossref","is-referenced-by-count":8,"title":["ELISL: early\u2013late integrated synthetic lethality prediction in cancer"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-6678","authenticated-orcid":false,"given":"Yasin I","family":"Tepeli","sequence":"first","affiliation":[{"name":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1716-8419","authenticated-orcid":false,"given":"Colm","family":"Seale","sequence":"additional","affiliation":[{"name":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"},{"name":"Holland Proton Therapy Center (HollandPTC) , Delft, The Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-9627","authenticated-orcid":false,"given":"Joana P","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Pattern Recognition & Bioinformatics, Department of Intelligent Systems, Faculty EEMCS, Delft University of Technology , Delft, The Netherlands"}]}],"member":"286","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"2024011113064429700_btad764-B1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41571-018-0055-6","article-title":"Synthetic lethal therapies for cancer: what\u2019s next after PARP inhibitors?","volume":"15","author":"Ashworth","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"2024011113064429700_btad764-B2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nature11003","article-title":"The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity","volume":"483","author":"Barretina","year":"2012","journal-title":"Nature"},{"key":"2024011113064429700_btad764-B3","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledge base in 2021","volume":"49","author":"","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024011113064429700_btad764-B4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: biology, pathophysiology and therapy","volume":"8","author":"Beenken","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"2024011113064429700_btad764-B5","doi-asserted-by":"crossref","first-page":"114626","DOI":"10.18632\/oncotarget.22638","article-title":"Genetic variation in the NEIL2 DNA glycosylase gene is associated with oxidative DNA damage in BRCA2 mutation carriers","volume":"8","author":"Ben\u00edtez-Buelga","year":"2017","journal-title":"Oncotarget"},{"key":"2024011113064429700_btad764-B6","doi-asserted-by":"crossref","first-page":"20007","DOI":"10.1073\/pnas.0710052104","article-title":"Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma","volume":"104","author":"Beroukhim","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011113064429700_btad764-B7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/PPO.0000000000000554","article-title":"PARP inhibitors in pancreatic cancer","volume":"27","author":"Brown","year":"2021","journal-title":"Cancer J"},{"key":"2024011113064429700_btad764-B8","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1093\/bioinformatics\/btaa211","article-title":"Dual-dropout graph convolutional network for predicting synthetic lethality in human cancers","volume":"36","author":"Cai","year":"2020","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data: figure 1","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov"},{"key":"2024011113064429700_btad764-B10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrd3374","article-title":"Harnessing synthetic lethal interactions in anticancer drug discovery","volume":"10","author":"Chan","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"2024011113064429700_btad764-B11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)81374-4","article-title":"Dual roles for patched in sequestering and transducing hedgehog","volume":"87","author":"Chen","year":"1996","journal-title":"Cell"},{"key":"2024011113064429700_btad764-B12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/bioinformatics\/bty673","article-title":"DiscoverSL: an R package for multi-omic data driven prediction of synthetic lethality in cancers","volume":"35","author":"Das","year":"2018","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B13","author":"","year":"2019"},{"key":"2024011113064429700_btad764-B14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ymeth.2017.07.007","article-title":"Identifying synthetic lethal targets using CRISPR\/cas9 system","volume":"131","author":"Dhanjal","year":"2017","journal-title":"Methods"},{"key":"2024011113064429700_btad764-B15","doi-asserted-by":"crossref","first-page":"19489","DOI":"10.1073\/pnas.1314302110","article-title":"Synthetic lethality between CCNE1 amplification and loss of BRCA1","volume":"110","author":"Etemadmoghadam","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024011113064429700_btad764-B16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ccell.2019.01.009","article-title":"A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK","volume":"35","author":"Feng","year":"2019","journal-title":"Cancer Cell"},{"key":"2024011113064429700_btad764-B17","first-page":"177","article-title":"All Models are Wrong, but Many are Useful: Learning a Variable\u2019s Importance by Studying an Entire Class of Prediction Models Simultaneously","volume-title":"J Mach Learn Res","author":"Fisher","year":"2019"},{"key":"2024011113064429700_btad764-B18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0900212","article-title":"Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers","volume":"361","author":"Fong","year":"2009","journal-title":"N Engl J Med"},{"key":"2024011113064429700_btad764-B19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1214\/aos\/1013203451","article-title":"Greedy function approximation: a gradient boosting machine","volume":"29","author":"Friedman","year":"2001","journal-title":"Ann Statist"},{"key":"2024011113064429700_btad764-B20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-generation characterization of the cancer cell line encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"2024011113064429700_btad764-B21","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.18632\/oncotarget.2726","article-title":"Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma","volume":"6","author":"Graab","year":"2015","journal-title":"Oncotarget"},{"key":"2024011113064429700_btad764-B22","author":"Grover","year":"2016"},{"key":"2024011113064429700_btad764-B23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1186\/s12859-019-3220-8","article-title":"Modeling aspects of the language of life through transfer-learning protein sequences","volume":"20","author":"Heinzinger","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2024011113064429700_btad764-B24","first-page":"278","author":"Ho"},{"key":"2024011113064429700_btad764-B25","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1186\/s12859-019-3197-3","article-title":"Predicting synthetic lethal interactions in human cancers using graph regularized self-representative matrix factorization","volume":"20","author":"Huang","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2024011113064429700_btad764-B26","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1101\/gad.212548.112","article-title":"Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5a","volume":"27","author":"Hubert","year":"2013","journal-title":"Genes Dev"},{"key":"2024011113064429700_btad764-B27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrclinonc.2010.143","article-title":"PARP inhibitor olaparib is safe and effective in patients with BRCA1 and BRCA2 mutations","volume":"7","author":"Hutchinson","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"2024011113064429700_btad764-B28","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev"},{"key":"2024011113064429700_btad764-B29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1476-4598-11-26","article-title":"Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin","volume":"11","author":"Jacquemont","year":"2012","journal-title":"Mol Cancer"},{"key":"2024011113064429700_btad764-B30","doi-asserted-by":"crossref","first-page":"D412","DOI":"10.1093\/nar\/gkn760","article-title":"STRING 8\u2013a global view on proteins and their functional interactions in 630 organisms","volume":"37","author":"Jensen","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2024011113064429700_btad764-B31","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.cell.2014.07.027","article-title":"Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality","volume":"158","author":"Jerby-Arnon","year":"2014","journal-title":"Cell"},{"key":"2024011113064429700_btad764-B32","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1158\/2159-8290.CD-11-0336","article-title":"Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer","volume":"2","author":"Juvekar","year":"2012","journal-title":"Cancer Discov"},{"key":"2024011113064429700_btad764-B33","doi-asserted-by":"crossref","first-page":"e13349","DOI":"10.15252\/emmm.202013349","article-title":"WNT inhibition creates a BRCA-like state in Wnt-addicted cancer","volume":"13","author":"Kaur","year":"2021","journal-title":"EMBO Mol Med"},{"key":"2024011113064429700_btad764-B34","first-page":"181","article-title":"A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis","volume":"33","author":"Kranz","year":"2014","journal-title":"EMBO J"},{"key":"2024011113064429700_btad764-B35","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/bioinformatics\/btx624","article-title":"DeepGO: predicting protein functions from sequence and interactions using a deep ontology-aware classifier","volume":"34","author":"Kulmanov","year":"2017","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B36","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1038\/s41467-018-04647-1","article-title":"Harnessing synthetic lethality to predict the response to cancer treatment","volume":"9","author":"Lee","year":"2018","journal-title":"Nat Commun"},{"key":"2024011113064429700_btad764-B37","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1093\/bioinformatics\/btz893","article-title":"Predicting synthetic lethal interactions using heterogeneous data sources","volume":"36","author":"Liany","year":"2019","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B38","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B39","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1109\/TCBB.2019.2909908","article-title":"SL2mf: predicting synthetic lethality in human cancers via logistic matrix factorization","volume":"17","author":"Liu","year":"2020","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"2024011113064429700_btad764-B40","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/bioinformatics\/btab110","article-title":"Graph contextualized attention network for predicting synthetic lethality in human cancers","volume":"37","author":"Long","year":"2021","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B41","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nat Genet"},{"key":"2024011113064429700_btad764-B42","doi-asserted-by":"crossref","first-page":"e0125795","DOI":"10.1371\/journal.pone.0125795","article-title":"Predicting human genetic interactions from cancer genome evolution","volume":"10","author":"Lu","year":"2015","journal-title":"PLoS One"},{"key":"2024011113064429700_btad764-B43","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/384176a0","article-title":"Biochemical evidence that patched is the hedgehog receptor","volume":"384","author":"Marigo","year":"1996","journal-title":"Nature"},{"key":"2024011113064429700_btad764-B44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.celrep.2017.06.061","article-title":"A role for mitochondrial translation in promotion of viability in K-Ras mutant cells","volume":"20","author":"Martin","year":"2017","journal-title":"Cell Rep"},{"key":"2024011113064429700_btad764-B45","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/ng.3984","article-title":"Computational correction of copy number effect improves specificity of CRISPR\u2013cas9 essentiality screens in cancer cells","volume":"49","author":"Meyers","year":"2017","journal-title":"Nat Genet"},{"key":"2024011113064429700_btad764-B46","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/gut.2010.211557","article-title":"Epidemiology, management and prognosis of colorectal cancer with lung metastases: a 30-year population-based study","volume":"59","author":"Mitry","year":"2010","journal-title":"Gut"},{"key":"2024011113064429700_btad764-B47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/sj.cr.7290260","article-title":"Wnt signaling in disease and in development","volume":"15","author":"Nusse","year":"2005","journal-title":"Cell Res"},{"key":"2024011113064429700_btad764-B48","doi-asserted-by":"crossref","first-page":"e1004256","DOI":"10.1371\/journal.pgen.1004256","article-title":"DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers","volume":"10","author":"Osorio","year":"2014","journal-title":"PLoS Genetics"},{"key":"2024011113064429700_btad764-B49","first-page":"442","author":"Parsons","year":"2016"},{"key":"2024011113064429700_btad764-B50","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.3389\/fimmu.2019.02872","article-title":"Wnt signaling and its significance within the tumor microenvironment: novel therapeutic insights","volume":"10","author":"Patel","year":"2019","journal-title":"Front Immunol"},{"key":"2024011113064429700_btad764-B51","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0039-6109(02)00051-8","article-title":"Colorectal metastasis (liver and lung)","volume":"82","author":"Penna","year":"2002","journal-title":"Surg Clin N Am"},{"key":"2024011113064429700_btad764-B52","first-page":"71","author":"","year":"2012"},{"key":"2024011113064429700_btad764-B53","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1093\/bioinformatics\/btac523","article-title":"Overcoming selection bias in synthetic lethality prediction","volume":"38","author":"Seale","year":"2022","journal-title":"Bioinformatics"},{"key":"2024011113064429700_btad764-B54","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1158\/2159-8290.CD-20-1503","article-title":"Synthetic lethality in cancer therapeutics: the next generation","volume":"11","author":"Setton","year":"2021","journal-title":"Cancer Discov"},{"key":"2024011113064429700_btad764-B55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13062-015-0086-1","article-title":"Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer","volume":"10","author":"Srihari","year":"2015","journal-title":"Biol Direct"},{"key":"2024011113064429700_btad764-B56","author":"TCGA GDAC","year":"2016"},{"key":"2024011113064429700_btad764-B57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13045-021-01061-x","article-title":"Prostate cancer and PARP inhibitors: progress and challenges","volume":"14","author":"Teyssonneau","year":"2021","journal-title":"J Hematol Oncol"},{"key":"2024011113064429700_btad764-B58","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.celrep.2015.11.021","article-title":"Genome-wide CRISPR-cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in glioblastoma stem-like cells","volume":"13","author":"Toledo","year":"2015","journal-title":"Cell Rep"},{"key":"2024011113064429700_btad764-B59","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fphar.2020.00112","article-title":"EXP2sl: a machine learning framework for cell-line-specific synthetic lethality prediction","volume":"11","author":"Wan","year":"2020","journal-title":"Front Pharmacol"},{"key":"2024011113064429700_btad764-B60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2105-8-391","article-title":"Analysis on multi-domain cooperation for predicting protein-protein interactions","volume":"8","author":"Wang","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"2024011113064429700_btad764-B61","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1038\/ncomms5828","article-title":"Widespread genetic epistasis among cancer genes","volume":"5","author":"Wang","year":"2014","journal-title":"Nat Commun"},{"key":"2024011113064429700_btad764-B62","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12864-016-2375-1","article-title":"Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs","volume":"17","author":"Wappett","year":"2016","journal-title":"BMC Genomics"},{"key":"2024011113064429700_btad764-B63","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41467-021-21544-2","article-title":"The tumor therapy landscape of synthetic lethality","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"2024011113064429700_btad764-B64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.inffus.2018.09.012","article-title":"Machine learning for integrating data in biology and medicine: principles, practice, and opportunities","volume":"50","author":"Zitnik","year":"2019","journal-title":"Inf Fusion"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btad764\/54642226\/btad764.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/40\/1\/btad764\/55432096\/btad764.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/40\/1\/btad764\/55432096\/btad764.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:15:00Z","timestamp":1704960900000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btad764\/7479688"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btad764","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.19.508413","asserted-by":"object"}]},"ISSN":["1367-4811"],"issn-type":[{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2023,12,19]]},"article-number":"btad764"}}