{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:22:46Z","timestamp":1772151766067,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["R15GM131390"],"award-info":[{"award-number":["R15GM131390"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA258584"],"award-info":[{"award-number":["R01CA258584"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["U01CA249245"],"award-info":[{"award-number":["U01CA249245"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["R01GM140012"],"award-info":[{"award-number":["R01GM140012"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["R01GM141519"],"award-info":[{"award-number":["R01GM141519"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"CPRIT","doi-asserted-by":"publisher","award":["RP230330"],"award-info":[{"award-number":["RP230330"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Non-informative or diffuse prior distributions are widely employed in Bayesian data analysis to maintain objectivity. However, when meaningful prior information exists and can be identified, using an informative prior distribution to accurately reflect current knowledge may lead to superior outcomes and great efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We propose MetaNorm, a Bayesian algorithm for normalizing NanoString nCounter gene expression data. MetaNorm is based on RCRnorm, a powerful method designed under an integrated series of hierarchical models that allow various sources of error to be explained by different types of probes in the nCounter system. However, a lack of accurate prior information, weak computational efficiency, and instability of estimates that sometimes occur weakens the approach despite its impressive performance. MetaNorm employs priors carefully constructed from a rigorous meta-analysis to leverage information from large public data. Combined with additional algorithmic enhancements, MetaNorm improves RCRnorm by yielding more stable estimation of normalized values, better convergence diagnostics and superior computational efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>R Code for replicating the meta-analysis and the normalization function can be found at github.com\/jbarth216\/MetaNorm.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btae024","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T17:40:30Z","timestamp":1705081230000},"source":"Crossref","is-referenced-by-count":2,"title":["MetaNorm: incorporating meta-analytic priors into normalization of NanoString nCounter data"],"prefix":"10.1093","volume":"40","author":[{"given":"Jackson","family":"Barth","sequence":"first","affiliation":[{"name":"Department of Statistics and Data Science, Southern Methodist University , Dallas, TX 75275, United States"},{"name":"Department of Statistical Science, Baylor University , Waco, TX 76798, United States"}]},{"given":"Yuqiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Statistics and Data Science, Southern Methodist University , Dallas, TX 75275, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-9883","authenticated-orcid":false,"given":"Guanghua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Quantitative Biomedical Research Center, The University of Texas Southwestern Medical Center , Dallas, TX 75390, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-6511","authenticated-orcid":false,"given":"Xinlei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics and Data Science, Southern Methodist University , Dallas, TX 75275, United States"},{"name":"Department of Mathematics, University of Texas at Arlington , Arlington, TX 76019 United States"},{"name":"Division of Data Science, College of Science, University of Texas at Arlington , Arlington, TX 76019, United States"}]}],"member":"286","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"2024013017453820000_btae024-B2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1214\/088342304000000116","article-title":"The interplay of Bayesian and frequentist analysis","volume":"19","author":"Bayarri","year":"2004","journal-title":"Statist Sci"},{"key":"2024013017453820000_btae024-B3","doi-asserted-by":"crossref","first-page":"bbaa163","DOI":"10.1093\/bib\/bbaa163","article-title":"An approach for normalization and quality control for nanostring RNA expression data","volume":"22","author":"Bhattacharya","year":"2021","journal-title":"Brief Bioinform"},{"key":"2024013017453820000_btae024-B4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/01621459.2017.1285773","article-title":"Variational 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