{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:07:05Z","timestamp":1775542025444,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["99025741"],"award-info":[{"award-number":["99025741"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Drug repurposing is a viable solution for reducing the time and cost associated with drug development. However, thus far, the proposed drug repurposing approaches still need to meet expectations. Therefore, it is crucial to offer a systematic approach for drug repurposing to achieve cost savings and enhance human lives. In recent years, using biological network-based methods for drug repurposing has generated promising results. Nevertheless, these methods have limitations. Primarily, the scope of these methods is generally limited concerning the size and variety of data they can effectively handle. Another issue arises from the treatment of heterogeneous data, which needs to be addressed or converted into homogeneous data, leading to a loss of information. A significant drawback is that most of these approaches lack end-to-end functionality, necessitating manual implementation and expert knowledge in certain stages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We propose a new solution, Heterogeneous Graph Transformer for Drug Repurposing (HGTDR), to address the challenges associated with drug repurposing. HGTDR is a three-step approach for knowledge graph-based drug repurposing: (1) constructing a heterogeneous knowledge graph, (2) utilizing a heterogeneous graph transformer network, and (3) computing relationship scores using a fully connected network. By leveraging HGTDR, users gain the ability to manipulate input graphs, extract information from diverse entities, and obtain their desired output. In the evaluation step, we demonstrate that HGTDR performs comparably to previous methods. Furthermore, we review medical studies to validate our method\u2019s top 10 drug repurposing suggestions, which have exhibited promising results. We also demonstrated HGTDR\u2019s capability to predict other types of relations through numerical and experimental validation, such as drug\u2013protein and disease\u2013protein inter-relations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The source code and data are available at https:\/\/github.com\/bcb-sut\/HGTDR and http:\/\/git.dml.ir\/BCB\/HGTDR<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btae349","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T18:50:43Z","timestamp":1719255043000},"source":"Crossref","is-referenced-by-count":36,"title":["HGTDR: Advancing drug repurposing with heterogeneous graph transformers"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5969-116X","authenticated-orcid":false,"given":"Ali","family":"Gharizadeh","sequence":"first","affiliation":[{"name":"Department of Computer Engineering, Sharif University of Technology , Tehran, P.O. Box 11155-9517, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-8864","authenticated-orcid":false,"given":"Karim","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Sharif University of Technology , Tehran, P.O. Box 11155-9517, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-283X","authenticated-orcid":false,"given":"Amin","family":"Ghareyazi","sequence":"additional","affiliation":[{"name":"Department of Computer Engineering, Sharif University of Technology , Tehran, P.O. Box 11155-9517, Iran"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-4859","authenticated-orcid":false,"given":"Mohammad R K","family":"Mofrad","sequence":"additional","affiliation":[{"name":"Departments of Bioengineering and Mechanical Engineering, University of California , Berkeley, CA, P.O. 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