{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:25:20Z","timestamp":1772677520136,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pasteur-Roux-Cantarini fellowship of Institut Pasteur to C.B.C"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Protein Interaction Explorer (PIE) is a new web-based tool integrated to our database iPPI-DB, specifically crafted to support structure-based drug discovery initiatives focused on protein\u2013protein interactions (PPIs). Drawing upon extensive structural data encompassing thousands of heterodimer complexes, including those with successful ligands, PIE provides a comprehensive suite of tools dedicated to aid decision-making in PPI drug discovery. PIE enables researchers\/bioinformaticians to identify and characterize crucial factors such as the presence of binding pockets or functional binding sites at the interface, predicting hot spots, and foreseeing similar protein-embedded pockets for potential repurposing efforts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>PIE is user-friendly and readily accessible at https:\/\/ippidb.pasteur.fr\/targetcentric\/. It relies on the NGL visualizer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btae414","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T20:13:51Z","timestamp":1719346431000},"source":"Crossref","is-referenced-by-count":3,"title":["Protein interaction explorer (PIE): a comprehensive platform for navigating protein\u2013protein interactions and ligand binding pockets"],"prefix":"10.1093","volume":"40","author":[{"given":"Fabien","family":"Mareuil","sequence":"first","affiliation":[{"name":"Bioinformatics and Biostatistics Hub, D\u00e9partement Biologie Computationnelle, Institut Pasteur, USR 3756 CNRS , 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Moine-Franel","sequence":"additional","affiliation":[{"name":"Structural Bioinformatics Unit, Department of Structural Biology and Chemistry, Institut Pasteur, Universit\u00e9 de Paris, CNRS UMR3528 , 75015 Paris, 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