{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:54:43Z","timestamp":1784044483897,"version":"3.55.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2023YFF1204901"],"award-info":[{"award-number":["2023YFF1204901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122065"],"award-info":[{"award-number":["82122065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073698"],"award-info":[{"award-number":["82073698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2022YFH0027"],"award-info":[{"award-number":["2022YFH0027"]}]},{"name":"Basic Research Foundation of Sichuan University","award":["2023SCUH0073"],"award-info":[{"award-number":["2023SCUH0073"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2024A1515030161"],"award-info":[{"award-number":["2024A1515030161"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Target discovery is a crucial step in drug development, as it directly affects the success rate of clinical trials. Knowledge graphs (KGs) offer unique advantages in processing complex biological data and inferring new relationships. Existing biomedical KGs primarily focus on tasks such as drug repositioning and drug\u2013target interactions, leaving a gap in the construction of KGs tailored for target discovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We established a comprehensive biomedical KG focusing on target discovery, termed TarKG, by integrating seven existing biomedical KGs, nine public databases, and traditional Chinese medicine knowledge databases. TarKG consists of 1\u00a0143\u00a0313 entities and 32\u00a0806\u00a0467 relations across 15 entity categories and 171 relation types, all centered around 3 core entity types: Disease, Gene, and Compound. TarKG provides specialized knowledges for the core entities including chemical structures, protein sequences, or text descriptions. By using different KG embedding algorithms, we assessed the knowledge completion capabilities of TarKG, particularly for disease\u2013target link prediction. In case studies, we further examined TarKG\u2019s ability to predict potential protein targets for Alzheimer\u2019s disease (AD) and to identify diseases potentially associated with the metallo-deubiquitinase CSN5, using literature analysis for validation. Furthermore, we provided a user-friendly web server (https:\/\/tarkg.ddtmlab.org) that enables users to perform knowledge retrieval and relation inference using TarKG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>TarKG is accessible at https:\/\/tarkg.ddtmlab.org.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btae598","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T14:00:03Z","timestamp":1728655203000},"source":"Crossref","is-referenced-by-count":19,"title":["TarKG: a comprehensive biomedical knowledge graph for target discovery"],"prefix":"10.1093","volume":"40","author":[{"given":"Cong","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chui-Pu","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Data Intelligence, Department of Computer Science, Shantou University , Shantou 515063,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tian","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Song","family":"Fang","sequence":"additional","affiliation":[{"name":"Science and Technology Innovation Center, Guangzhou University of Chinese Medicine , Guangzhou 510405,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-6677","authenticated-orcid":false,"given":"Guo-Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University , Chengdu 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"2024102718413406400_btae598-B1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"2024102718413406400_btae598-B2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/d41573-024-00011-9","article-title":"2023 FDA approvals: unprecedented volume at moderate value","volume":"23","author":"Baedeker","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"2024102718413406400_btae598-B3","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1038\/s41467-023-39301-y","article-title":"Biomedical knowledge graph learning for drug repurposing by extending guilt-by-association to multiple layers","volume":"14","author":"Bang","year":"2023","journal-title":"Nat Commun"},{"key":"2024102718413406400_btae598-B4","doi-asserted-by":"crossref","first-page":"D1305","DOI":"10.1093\/nar\/gkad1051","article-title":"The DO-KB knowledgebase: a 20-year journey developing the disease open science ecosystem","volume":"52","author":"Baron","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B5","first-page":"48","article-title":"Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update","volume":"2","author":"Bethune","year":"2010","journal-title":"J Thorac Dis"},{"key":"2024102718413406400_btae598-B6","first-page":"2787","author":"Bordes","year":"2013"},{"key":"2024102718413406400_btae598-B7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1287\/msom.2020.0963","article-title":"Flexible drug approval policies","volume":"24","author":"Bravo","year":"2022","journal-title":"M&SOM"},{"key":"2024102718413406400_btae598-B8","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1093\/bioinformatics\/btaa274","article-title":"OpenBioLink: a benchmarking framework for large-scale biomedical link prediction","volume":"36","author":"Breit","year":"2020","journal-title":"Bioinformatics"},{"key":"2024102718413406400_btae598-B9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41597-023-01960-3","article-title":"Building a knowledge graph to enable precision medicine","volume":"10","author":"Chandak","year":"2023","journal-title":"Sci Data"},{"key":"2024102718413406400_btae598-B10","doi-asserted-by":"crossref","first-page":"107839","DOI":"10.1016\/j.neuropharm.2019.107839","article-title":"The 5-HT6 receptor interactome: new insight in receptor signaling and its impact on brain physiology and pathologies","volume":"172","author":"Chaumont-Dubel","year":"2020","journal-title":"Neuropharmacology"},{"key":"2024102718413406400_btae598-B11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jocn.2022.10.023","article-title":"Pioglitazone use is associated with reduced risk of Parkinson\u2019s disease in patients with diabetes: a systematic review and meta-analysis","volume":"106","author":"Chen","year":"2022","journal-title":"J Clin Neurosci"},{"key":"2024102718413406400_btae598-B12","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1001\/jama.2020.8648","article-title":"Research and development costs of new drugs","volume":"324","author":"DiMasi","year":"2020","journal-title":"JAMA"},{"key":"2024102718413406400_btae598-B13","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1021\/acs.jcim.4c00737","article-title":"Knowledge graph convolutional network with heuristic search for drug repositioning","volume":"64","author":"Du","year":"2024","journal-title":"J Chem Inf Model"},{"key":"2024102718413406400_btae598-B14","doi-asserted-by":"crossref","first-page":"D1197","DOI":"10.1093\/nar\/gkaa1063","article-title":"HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine","volume":"49","author":"Fang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B15","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3390\/cancers13071513","article-title":"Dysregulation of the ubiquitin proteasome system in human malignancies: a window for therapeutic intervention","volume":"13","author":"Fhu","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2024102718413406400_btae598-B16","doi-asserted-by":"crossref","first-page":"e26726","DOI":"10.7554\/eLife.26726","article-title":"Systematic integration of biomedical knowledge prioritizes drugs for repurposing","volume":"6","author":"Himmelstein","year":"2017","journal-title":"Elife"},{"key":"2024102718413406400_btae598-B17","author":"Ioannidis","year":"2020"},{"key":"2024102718413406400_btae598-B18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12883-021-02215-7","article-title":"Study of the collagen type VI alpha 3 (COL6A3) gene in Parkinson\u2019s disease","volume":"21","author":"Jin","year":"2021","journal-title":"BMC Neurol"},{"key":"2024102718413406400_btae598-B19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2024102718413406400_btae598-B20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0006-8993(97)01202-X","article-title":"Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease","volume":"780","author":"Kitamura","year":"1998","journal-title":"Brain Res"},{"key":"2024102718413406400_btae598-B21","doi-asserted-by":"crossref","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank 6.0: the DrugBank Knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B22","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gkad926","article-title":"BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins","volume":"52","author":"Kong","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B23","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.4110\/in.2018.18.e4","article-title":"Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules","volume":"18","author":"Li","year":"2018","journal-title":"Immune Netw"},{"key":"2024102718413406400_btae598-B24","first-page":"2181","author":"Lin","year":"2015"},{"key":"2024102718413406400_btae598-B25","first-page":"265","article-title":"Medical Subject Headings (MeSH)","volume":"88","author":"Lipscomb","year":"2000","journal-title":"Bull Med Libr Assoc"},{"key":"2024102718413406400_btae598-B26","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s12031-018-1238-4","article-title":"Over-expression of 5-HT6 receptor and activated jab-1\/p-c-jun play important roles in pilocarpine-induced seizures and learning-memory impairment","volume":"67","author":"Liu","year":"2019","journal-title":"J Mol Neurosci"},{"key":"2024102718413406400_btae598-B27","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1021\/acs.jcim.3c00365","article-title":"DCABM-TCM: a database of constituents absorbed into the blood and metabolites of traditional Chinese medicine","volume":"63","author":"Liu","year":"2023","journal-title":"J Chem Inf Model"},{"key":"2024102718413406400_btae598-B28","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1038\/s41467-023-42233-2","article-title":"Expanding PROTACtable genome universe of E3 ligases","volume":"14","author":"Liu","year":"2023","journal-title":"Nat Commun"},{"key":"2024102718413406400_btae598-B29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3389\/fphar.2020.00439","article-title":"TCMIO: a comprehensive database of traditional Chinese medicine on immuno-oncology","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharmacol"},{"key":"2024102718413406400_btae598-B30","doi-asserted-by":"crossref","first-page":"D1124","DOI":"10.1093\/nar\/gks1047","article-title":"NPACT: naturally occurring plant-based anti-cancer compound-activity-target database","volume":"41","author":"Mangal","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B31","first-page":"809","volume-title":"Proceedings of the 28th International Conference on International Conference on Machine Learning","author":"Nickel","year":"2011"},{"key":"2024102718413406400_btae598-B32","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s11064-014-1454-4","article-title":"Apoptosis in Alzheimer\u2019s disease: an understanding of the physiology, pathology and therapeutic avenues","volume":"39","author":"Obulesu","year":"2014","journal-title":"Neurochem Res"},{"key":"2024102718413406400_btae598-B33","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3233\/JAD-190634","article-title":"Genome-Wide methylation of mild cognitive impairment in mexican Americans highlights genes involved in synaptic transport, Alzheimer\u2019s disease-precursor phenotypes, and metabolic morbidities","volume":"72","author":"Pathak","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"2024102718413406400_btae598-B34","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/s41467-021-21770-8","article-title":"Identification of disease treatment mechanisms through the multiscale interactome","volume":"12","author":"Ruiz","year":"2021","journal-title":"Nat Commun"},{"key":"2024102718413406400_btae598-B35","doi-asserted-by":"crossref","first-page":"1201419","DOI":"10.3389\/fddsv.2023.1201419","article-title":"Drug discovery and development: introduction to the general public and patient groups","volume":"3","author":"Singh","year":"2023","journal-title":"Front Drug Discov"},{"key":"2024102718413406400_btae598-B36","article-title":"Introducing the knowledge graph: things, not strings","author":"Singhal","year":"2012","journal-title":"Off Google Blog"},{"key":"2024102718413406400_btae598-B37","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.4049\/jimmunol.1101455","article-title":"JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression","volume":"188","author":"Sitte","year":"2012","journal-title":"J Immunol"},{"key":"2024102718413406400_btae598-B38","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1007\/s11427-022-2318-4","article-title":"TCMSTD 1.0: a systematic analysis of the traditional Chinese medicine system toxicology database","volume":"66","author":"Song","year":"2023","journal-title":"Sci China Life Sci"},{"key":"2024102718413406400_btae598-B39","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90% of clinical drug development fails and how to improve it?","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"2024102718413406400_btae598-B40","author":"Sun"},{"key":"2024102718413406400_btae598-B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bib\/bbad027","article-title":"Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM","volume":"24","author":"Tian","year":"2023","journal-title":"Brief Bioinformatics"},{"key":"2024102718413406400_btae598-B42","first-page":"2071","author":"Trouillon","year":"2016"},{"key":"2024102718413406400_btae598-B43","author":"Vasilevsky"},{"key":"2024102718413406400_btae598-B44","first-page":"3173","author":"Walsh","year":"2020"},{"key":"2024102718413406400_btae598-B45","doi-asserted-by":"crossref","article-title":"PubTator 3.0: an AI-powered literature resource for unlocking biomedical knowledge","author":"Wei","DOI":"10.1093\/nar\/gkae235"},{"key":"2024102718413406400_btae598-B46","doi-asserted-by":"crossref","first-page":"D1110","DOI":"10.1093\/nar\/gky1021","article-title":"SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping","volume":"47","author":"Wu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B47","doi-asserted-by":"crossref","first-page":"D1238","DOI":"10.1093\/nar\/gkab1011","article-title":"HIT 2.0: an enhanced platform for herbal ingredients' targets","volume":"50","author":"Yan","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B48","author":"Yang","year":"2015"},{"key":"2024102718413406400_btae598-B49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13578-022-00828-0","article-title":"Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases","volume":"12","author":"Yang","year":"2022","journal-title":"Cell Biosci"},{"key":"2024102718413406400_btae598-B50","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1016\/j.csbj.2023.11.030","article-title":"ccTCM: a quantitative component and compound platform for promoting the research of traditional Chinese medicine","volume":"21","author":"Yang","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"key":"2024102718413406400_btae598-B51","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Azheimer\u2019s disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J"},{"key":"2024102718413406400_btae598-B52","doi-asserted-by":"crossref","first-page":"D1233","DOI":"10.1093\/nar\/gkaa755","article-title":"INTEDE: interactome of drug-metabolizing enzymes","volume":"49","author":"Yin","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B53","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gkac860","article-title":"MeDBA: the metalloenzyme data bank and analysis platform","volume":"51","author":"Yu","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B54","doi-asserted-by":"crossref","first-page":"D1180","DOI":"10.1093\/nar\/gkad1004","article-title":"The ChEMBL database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods","volume":"52","author":"Zdrazil","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2024102718413406400_btae598-B55","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.scib.2022.03.013","article-title":"SoFDA: an integrated web platform from syndrome ontology to network-based evaluation of disease\u2013syndrome\u2013formula associations for precision medicine","volume":"67","author":"Zhang","year":"2022","journal-title":"Sci Bull (Beijing)"},{"key":"2024102718413406400_btae598-B56","first-page":"739","author":"Zheng","year":"2020"},{"key":"2024102718413406400_btae598-B57","first-page":"1","article-title":"PharmKG: a dedicated knowledge graph benchmark for bomedical data mining","volume":"22","author":"Zheng","year":"2020","journal-title":"Brief Bioinf"},{"key":"2024102718413406400_btae598-B58","doi-asserted-by":"crossref","first-page":"D1398","DOI":"10.1093\/nar\/gkab953","article-title":"Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents","volume":"50","author":"Zhou","year":"2022","journal-title":"Nucleic Acids Res"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btae598\/59720608\/btae598.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/40\/10\/btae598\/60136087\/btae598.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/40\/10\/btae598\/60136087\/btae598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T18:42:33Z","timestamp":1730054553000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btae598\/7818343"}},"subtitle":[],"editor":[{"given":"Jonathan","family":"Wren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btae598","relation":{},"ISSN":["1367-4811"],"issn-type":[{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10,1]]},"article-number":"btae598"}}