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We introduce nipalsMCIA, an implementation of multiple co-inertia analysis (MCIA) for joint dimensionality reduction that solves the objective function using an extension to Nonlinear Iterative Partial Least Squares. We applied nipalsMCIA to both bulk and single-cell datasets and observed significant speed-up over other implementations for data with a large sample size and\/or feature dimension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>nipalsMCIA is available as a Bioconductor package at https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/nipalsMCIA.html, and includes detailed documentation and application vignettes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf015","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T15:24:58Z","timestamp":1736436298000},"source":"Crossref","is-referenced-by-count":2,"title":["<tt>nipalsMCIA<\/tt>\n                    : flexible multi-block dimensionality reduction in R via nonlinear iterative partial least 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