{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:31Z","timestamp":1772138071321,"version":"3.50.1"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Targets","award":["OTAR3001"],"award-info":[{"award-number":["OTAR3001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>The Open Targets Platform (https:\/\/platform.opentargets.org) is a unique, comprehensive, open-source resource supporting systematic identification and prioritisation of targets for drug discovery. The Platform combines, harmonizes and integrates data from &amp;gt;20 diverse sources to provide target\u2013disease associations, covering evidence derived from genetic associations, somatic mutations, known drugs, differential expression, animal models, pathways and systems biology. An in-house target identification scoring framework weighs the evidence from each data source and type, contributing to an overall score for each of the 7.8M target\u2013disease associations. However, the old infrastructure did not allow user-led dynamic adjustments in the contribution of different evidence types for target prioritisation, a limitation frequently raised by our user community. Furthermore, the previous Platform user interface did not support navigation and exploration of the underlying target\u2013disease evidence on the same page, occasionally making the user journey counterintuitive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we describe \u2018Associations on the Fly\u2019 (AOTF), a new Platform feature\u2014developed with a user-centred vision\u2014that enables the user to formulate more flexible therapeutic hypotheses through dynamic adjustment of the weight of contributing evidence from each source, altering the prioritisation of targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The codebases that power the Platform\u2014including our pipelines, GraphQL API, and React UI\u2014are all open source and licensed under the APACHE LICENSE, VERSION 2.0. You can find all of our code repositories on GitHub at https:\/\/github.com\/opentargets and on Zenodo at https:\/\/zenodo.org\/records\/14392214. This tool was implemented using React v18 and its code is accessible here: (https:\/\/github.com\/opentargets\/ot-ui-apps). The tools are accessible through the Open Targets Platform web interface (https:\/\/platform.opentargets.org\/) and GraphQL API (https:\/\/platform-docs.opentargets.org\/data-access\/graphql-api). Data is available for download here: (https:\/\/platform.opentargets.org\/downloads) and from the EMBL-EBI FTP: (https:\/\/ftp.ebi.ac.uk\/pub\/databases\/opentargets\/platform\/).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf070","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T07:21:54Z","timestamp":1739172114000},"source":"Crossref","is-referenced-by-count":2,"title":["Associations on the Fly, a new feature aiming to facilitate exploration of the Open Targets Platform evidence"],"prefix":"10.1093","volume":"41","author":[{"given":"Carlos","family":"Cruz-Castillo","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Luca","family":"Fumis","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Chintan","family":"Mehta","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Ricardo Esteban","family":"Martinez-Osorio","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Juan Maria","family":"Roldan-Romero","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Helena","family":"Cornu","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Prashant","family":"Uniyal","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]},{"name":"Open Targets, Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}]},{"given":"Antonio","family":"Solano-Roman","sequence":"additional","affiliation":[{"name":"College of Arts, Media and Design, Northeastern University , Boston, MA, 02115,","place":["United States"]},{"name":"Flatiron Health , New York, NY, 10010,","place":["United States"]}]},{"given":"Miguel","family":"Carmona","sequence":"additional","affiliation":[{"name":"AstraZeneca UK Limited , Cambridge, CB2 0AA,","place":["United Kingdom"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1857-278X","authenticated-orcid":false,"given":"David","family":"Ochoa","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, 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