{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:44:35Z","timestamp":1753875875594,"version":"3.41.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["113-2311-B-039-001-MY3"],"award-info":[{"award-number":["113-2311-B-039-001-MY3"]}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004391","name":"China Medical University Hospital, Taiwan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004391","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Cancer Biology and Precision Therapeutics Center, China Medical University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Lipids play crucial roles in various biological functions and diseases. However, a gap exists in databases providing information of lipids functions based on curated information. Consequently, LipidFun is purposed as the first lipid function database with sentence-level evidence detailing lipid-related phenotypes and biological functions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Potential lipid functions were extracted from the biomedical literature using natural language processing techniques, with accuracy and reliability ensured through manual curation by four domain experts. LipidFun constructs classification systems for lipids, biological functions, and phenotypes for named entity recognition. Sentence-level evidence is extracted to highlight connections to lipid-associated biological processes and diseases. Integrating these classification systems and a large amount of sentence-level evidence allows LipidFun to provide an overview of lipid\u2013phenotype and lipid\u2013biological function associations through concise visualizations. Overall, LipidFun unravels the relationships between lipids and biological mechanisms, underscoring their overarching influence on physiological processes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>LipidFun is available at https:\/\/lipidfun.bioinfomics.org\/.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf110","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T19:05:17Z","timestamp":1741892717000},"source":"Crossref","is-referenced-by-count":0,"title":["LipidFun: a database of lipid functions"],"prefix":"10.1093","volume":"41","author":[{"given":"Wen-Jen","family":"Lin","sequence":"first","affiliation":[{"name":"School of Medicine, China Medical University , Taichung 404333,","place":["Taiwan"]},{"name":"Graduate Institute of Biomedical Science, China Medical University , Taichung 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