{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:43:46Z","timestamp":1772966626050,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2024-00405984"],"award-info":[{"award-number":["RS-2024-00405984"]}],"id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Program in Medical AI Semiconductor"},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["2024-0-0097"],"award-info":[{"award-number":["2024-0-0097"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2025-02304331"],"award-info":[{"award-number":["RS-2025-02304331"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Drug repositioning, identifying new therapeutic applications for existing drugs, can significantly reduce the time and cost involved in drug development. Recent studies have explored the use of Anatomical Therapeutic Chemical (ATC) codes in drug repositioning, offering a systematic framework to predict ATC codes for a drug. The ATC classification system organizes drugs according to their chemical properties, pharmacological actions, and therapeutic effects. However, its complex hierarchical structure and the limited scalability at higher levels present significant challenges for achieving accurate ATC code prediction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We propose a novel approach to predict ATC codes of drugs, named Feature Aggregation and Convolution with Transformer models (FACT). This method computes three types of drug similarities, incorporating ATC code similarity with hierarchical weights and masked drug\u2013ATC code associations. These features are then aggregated for each target drug\u2013ATC code pair and processed through a convolution-transformer encoder to generate three embeddings. The embeddings are finally used to estimate the probability of an association between the target pair. The experimental results demonstrate that the proposed method achieves an area under the receiver operating characteristic curve (AUROC) of 0.9805 and an area under the precision-recall curve of 0.9770 at level 4 of the ATC codes, outperforming the previous methods by 15.05% and 18.42%, respectively. This study highlights the effectiveness of integrating diverse drug features and the potential of transformer-based models in ATC code prediction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Source code of FACT is freely available at https:\/\/github.com\/knhc1234\/FACT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf184","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:03:41Z","timestamp":1752584621000},"page":"i77-i85","source":"Crossref","is-referenced-by-count":2,"title":["FACT: Feature Aggregation and Convolution with Transformers for predicting drug classification code"],"prefix":"10.1093","volume":"41","author":[{"given":"Gwang-Hyeon","family":"Yun","sequence":"first","affiliation":[{"name":"Division of Software, Yonsei University - Mirae Campus, Wonju-si, Gangwon-do 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