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However, IMS experiments tend to yield large datasets, routinely recording over 200\u00a0000 ion intensity values per mass spectrum and more than 100\u00a0000 pixels, i.e. spectra, per dataset. Traditionally, IMS data size challenges have been addressed by feature selection or extraction, such as by peak picking and peak integration. Selective data reduction techniques such as peak picking only retain certain parts of a mass spectrum, and often these describe only medium-to-high-abundance species. Since lower-intensity peaks and, for example, near-isobar species are sometimes missed, selective methods can potentially bias downstream analysis toward a subset of species in the data rather than considering all species measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We present an alternative to selective data reduction of IMS data that achieves similar data size reduction while better conserving the ion intensity profiles across all recorded m\/z-bins, thereby preserving full spectrum information. Our method utilizes a low-rank matrix completion model combined with a randomized sparse-format-aware algorithm to approximate IMS datasets. This representation offers reduced dimensionality and a data footprint comparable to peak picking but also captures complete spectral profiles, enabling comprehensive analysis and compression. We demonstrate improved preservation of lower signal-to-noise ratio signals and near-isobars, mitigation of selection bias, and reduced information loss compared to current state-of-the-art data reduction methods in IMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The source code is available at https:\/\/github.com\/vandeplaslab\/full_profile and data are available at https:\/\/doi.org\/10.4121\/a6efd47a-b4ec-493e-a742-70e8a369f788.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf247","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:27:28Z","timestamp":1746689248000},"source":"Crossref","is-referenced-by-count":4,"title":["Preserving full spectrum information in imaging mass spectrometry data reduction"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-8808","authenticated-orcid":false,"given":"Roger A R","family":"Moens","sequence":"first","affiliation":[{"name":"Delft Center for Systems and Control, Delft University of Technology , 2628 CD Delft, Zuid-Holland,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-6405","authenticated-orcid":false,"given":"Lukasz G","family":"Migas","sequence":"additional","affiliation":[{"name":"Delft Center for Systems and Control, Delft University of Technology , 2628 CD Delft, Zuid-Holland,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9447-815X","authenticated-orcid":false,"given":"Jacqueline M","family":"Van Ardenne","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Research Center, Vanderbilt University , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Chemistry, Vanderbilt University , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-8105","authenticated-orcid":false,"given":"Eric P","family":"Skaar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-5498","authenticated-orcid":false,"given":"Jeffrey M","family":"Spraggins","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Research Center, Vanderbilt University , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Chemistry, Vanderbilt University , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Cell and Developmental Biology, Vanderbilt University , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Biochemistry, Vanderbilt University , Nashville, TN 37232,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2232-7130","authenticated-orcid":false,"given":"Raf","family":"Van de Plas","sequence":"additional","affiliation":[{"name":"Delft Center for Systems and Control, Delft University of Technology , 2628 CD Delft, Zuid-Holland,","place":["The Netherlands"]},{"name":"Mass Spectrometry Research Center, Vanderbilt University , Nashville, TN 37232,","place":["United States"]},{"name":"Department of Biochemistry, Vanderbilt University , Nashville, TN 37232,","place":["United 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