{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:24:59Z","timestamp":1771273499668,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union through NextGenerationEU, PNRR project ELIXIRxNextGenIT","award":["IR0000010"],"award-info":[{"award-number":["IR0000010"]}]},{"name":"National Center for Gene Therapy and Drugs based on RNA Technology","award":["CN00000041"],"award-info":[{"award-number":["CN00000041"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>In recent years, many disorder predictors have been developed to identify intrinsically disordered regions (IDRs) in proteins, achieving high accuracy. However, it may be difficult to interpret differences in predictions across methods. Consensus methods offer a simple solution, highlighting reliable predictions while filtering out uncertain positions. Here, we present a new version of MobiDB-lite, a consensus method designed to predict long IDRs and classify them based on compositional biases and conformational properties.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MobiDB-lite 4.0 pipeline was optimized to be ten times faster than the previous version. It now provides compactness annotations based on predicted apparent scaling exponent. The newly added features and disorder subclassifications allow the users to get a comprehensive insight into the protein\u2019s function and characteristics. MobiDB-lite 4.0 is integrated into the MobiDB and DisProt databases. A version without the compactness predictor is integrated into InterProScan, propagating MobiDB-lite annotations to UniProtKB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The MobiDB-lite 4.0 source code and a Docker container are available from the GitHub repository: https:\/\/github.com\/BioComputingUP\/MobiDB-lite.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf297","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T16:22:54Z","timestamp":1746894174000},"source":"Crossref","is-referenced-by-count":1,"title":["MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2044-541X","authenticated-orcid":false,"given":"Mahta","family":"Mehdiabadi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , 35131 Padova,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-4724","authenticated-orcid":false,"given":"Matthias","family":"Blum","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, Cambridgeshire CB10 1SD,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Tesei","sequence":"additional","affiliation":[{"name":"Structural Biology and NMR Laboratory, Linderstr\u00f8m-Lang Centre for Protein Science, Department of Biology, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f6ren","family":"von B\u00fclow","sequence":"additional","affiliation":[{"name":"Structural Biology and NMR Laboratory, Linderstr\u00f8m-Lang Centre for Protein Science, Department of Biology, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kresten","family":"Lindorff-Larsen","sequence":"additional","affiliation":[{"name":"Structural Biology and NMR Laboratory, Linderstr\u00f8m-Lang Centre for Protein Science, Department of Biology, University of Copenhagen , 2200 Copenhagen,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-7793","authenticated-orcid":false,"given":"Silvio C E","family":"Tosatto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, University of Padova , 35131 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