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However, current Network Medicine toolsets often lack computationally efficient data processing pipelines that support diverse scoring functions, network distance metrics, and null models. These limitations hamper their application in large-scale molecular screening, hypothesis testing, and ensemble modeling. To address these challenges, we introduce NetMedPy, a highly efficient and versatile computational package designed for comprehensive Network Medicine analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>NetMedPy is an open-source Python package under an MIT license. Source code, documentation, and installation instructions can be downloaded from https:\/\/github.com\/menicgiulia\/NetMedPy and https:\/\/pypi.org\/project\/NetMedPy. The package can run on any standard desktop computer or computing cluster.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf338","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T07:45:43Z","timestamp":1749887143000},"source":"Crossref","is-referenced-by-count":2,"title":["NetMedPy: a Python package for large-scale network medicine screening"],"prefix":"10.1093","volume":"41","author":[{"given":"Andres","family":"Aldana","sequence":"first","affiliation":[{"name":"Network Science Institute, Northeastern University , 177 Huntington Avenue, Boston, MA 02115,","place":["USA"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3347-7131","authenticated-orcid":false,"given":"Michael","family":"Sebek","sequence":"additional","affiliation":[{"name":"Network Science Institute, Northeastern University , 177 Huntington Avenue, Boston, MA 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