{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:20:08Z","timestamp":1760660408629,"version":"build-2065373602"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Canadian Statistical Sciences Institute (CANSSI) Quebec"},{"name":"Qu\u00e9bec Research Scholar"},{"name":"FRQ-Sant\u00e9"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Identifying disease-indicative genes is critical for deciphering disease mechanisms and has attracted significant interest in biomedical research. Spatial transcriptomics offers unprecedented insights for the detection of disease-associated genes by enabling within-tissue contrasts. However, this new technology poses challenges for conventional statistical models developed for RNA-sequencing, as these models often neglect the spatial corrleation of the disease status among tissue spots.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In this article, we propose DiSTect, a Bayesian shrinkage model to characterize the relationship between high-dimensional gene expressions and the disease status of each tissue spot, incorporating spatial correlation among these spots through autoregressive terms. Our model adopts a hierarchical structure to facilitate the analysis of multiple correlated samples and is further extended to accommodate the missing data within tissues. To ensure the model\u2019s applicability to datasets of varying sizes, we carry out two computational frameworks for Bayesian parameter estimation, tailored to both small and large sample scenarios. Simulation studies are conducted to evaluate the performance of the proposed model. The proposed model is applied to analyze the data arising from studies of HER2+ breast cancer and Alzheimer\u2019s disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The dataset and source code are available on GitHub (https:\/\/github.com\/StaGill\/DiSTect) and Zenodo (https:\/\/zenodo.org\/records\/17127211).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf530","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:26:21Z","timestamp":1758547581000},"source":"Crossref","is-referenced-by-count":0,"title":["DiSTect: a Bayesian model for disease-associated gene discovery and prediction in spatial transcriptomics"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2155-1781","authenticated-orcid":false,"given":"Qicheng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montreal, Quebec H3A 1G1,","place":["Canada"]}]},{"given":"Anji","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montreal, Quebec H3A 1G1,","place":["Canada"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1455-2159","authenticated-orcid":false,"given":"Qihuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics and Occupational Health, McGill University , Montreal, Quebec H3A 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