{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:59:26Z","timestamp":1764089966587,"version":"3.45.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Research Council"},{"name":"ARCHIMEDES","award":["101043848"],"award-info":[{"award-number":["101043848"]}]},{"name":"Tampere Institute for Advanced Study"},{"name":"Faculty of Pharmacy, University of Helsinki"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>OpTiles is an R package that dynamically defines tiling windows based on the distribution of sequenced CpGs, addressing the limitations of traditional fixed-tiling approaches in targeted methylation datasets. By integrating CpG density with intra-region methylation variability, it provides a reliability metric and extended functionality for annotating, prioritizing, and interpreting complex methylation data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>OpTiles is implemented in R and source code is freely available at https:\/\/github.com\/fhaive\/OpTiles. Data are available on Zenodo at https:\/\/doi.org\/10.5281\/zenodo.16961292.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf614","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:56:53Z","timestamp":1762606613000},"source":"Crossref","is-referenced-by-count":0,"title":["OpTiles: an R package for adaptive tiling and methylation variability profiling"],"prefix":"10.1093","volume":"41","author":[{"given":"Giorgia","family":"Migliaccio","sequence":"first","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]}]},{"given":"Lena","family":"M\u00f6bus","sequence":"additional","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]},{"name":"Tampere Institute for Advanced Study, Tampere University , 33520 Tampere,","place":["Finland"]}]},{"given":"Giusy","family":"del Giudice","sequence":"additional","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]},{"name":"Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki , 00790 Helsinki,","place":["Finland"]}]},{"given":"Jack","family":"Morikka","sequence":"additional","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]},{"name":"Tampere Institute for Advanced Study, Tampere University , 33520 Tampere,","place":["Finland"]}]},{"given":"Antonio","family":"Federico","sequence":"additional","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]},{"name":"Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki , 00790 Helsinki,","place":["Finland"]}]},{"given":"Angela","family":"Serra","sequence":"additional","affiliation":[{"name":"Finnish Hub for Development and Validation of Integrated Approaches (FHAIVE), Faculty of Medicine and Health Technology, Tampere University , 33100 Tampere,","place":["Finland"]},{"name":"Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki , 00790 Helsinki,","place":["Finland"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-9003","authenticated-orcid":false,"given":"Dario","family":"Greco","sequence":"additional","affiliation":[{"name":"Finnish 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