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However, a major bottleneck for global access is the absence of a user-friendly software capable of efficiently analyzing untargeted nanopore sequencing data to generate high-quality consensus genomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We share ViMOP, a pipeline built on our long-term experience in nanopore field sequencing. The pipeline emphasizes field user-friendliness, flexibility and versatility to analyze reads generated directly from human clinical samples. The software assembles de novo contigs, matches contigs to known viral references and uses them to assemble consensus genomes. Executed with a single Nextflow command or via the EPI2ME Desktop interface (ONT), results are summarized in an HTML report. ViMOP, through its user-centered design, lowers the barrier to high-quality virus genome reconstruction and advances capacity for genomic surveillance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>ViMOP is freely available for non-commercial use (https:\/\/github.com\/opr-group-bnitm\/vimop and https:\/\/zenodo.org\/records\/17913089), along with the associated database (https:\/\/zenodo.org\/records\/17652512), the scripts used to generate it (https:\/\/zenodo.org\/records\/17632662) and benchmarking code (https:\/\/zenodo.org\/records\/17633185).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaf687","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:44:18Z","timestamp":1766839458000},"source":"Crossref","is-referenced-by-count":2,"title":["ViMOP: a user-friendly and field-applicable pipeline for untargeted viral genome nanopore sequencing"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-3567","authenticated-orcid":false,"given":"Nils Peter","family":"Petersen","sequence":"first","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7677-5306","authenticated-orcid":false,"given":"Mia","family":"Le","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 Hamburg,","place":["Germany"]},{"name":"Institute for Computational Systems Biomedicine, University of Hamburg , 22761 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-6063","authenticated-orcid":false,"given":"Annick","family":"Renevey","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9968-0815","authenticated-orcid":false,"given":"Ehizojie","family":"Emua","sequence":"additional","affiliation":[{"name":"Viral and Emergent Pathogens Control and Research, Irrua Specialist Teaching Hospital , 310115 Irrua, Edo State,","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1597-9656","authenticated-orcid":false,"given":"Sarah","family":"Ryter","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1570-4624","authenticated-orcid":false,"given":"Giuditta","family":"Annibaldis","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-0206","authenticated-orcid":false,"given":"Jacob","family":"Camara","sequence":"additional","affiliation":[{"name":"Virology Research Center\/Laboratory of Viral Hemorrhagic Fevers , 001 Conakry, Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4506-6033","authenticated-orcid":false,"given":"Sanaba","family":"Boumbaly","sequence":"additional","affiliation":[{"name":"Virology Research Center\/Laboratory of Viral Hemorrhagic Fevers , 001 Conakry, Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-2495","authenticated-orcid":false,"given":"Cyril","family":"Erameh","sequence":"additional","affiliation":[{"name":"Viral and Emergent Pathogens Control and Research, Irrua Specialist Teaching Hospital , 310115 Irrua, Edo State,","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7922-7595","authenticated-orcid":false,"given":"Tanja","family":"Laske","sequence":"additional","affiliation":[{"name":"Institute for Computational Systems Biomedicine, University of Hamburg , 22761 Hamburg,","place":["Germany"]},{"name":"Leibniz Institute of Virology, Viral Systems Modeling , 20251 Hamburg,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0282-0462","authenticated-orcid":false,"given":"Jan","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Institute for Computational Systems Biomedicine, University of Hamburg , 22761 Hamburg,","place":["Germany"]},{"name":"Department of Mathematics and Computer Science, Computational Biomedicine Lab, University of Southern Denmark , 5230 Odense,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2826-5353","authenticated-orcid":false,"given":"Philippe","family":"Lemey","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Rega Institute , 3000 Leuven,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-0230","authenticated-orcid":false,"given":"Stephan","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Bernhard Nocht Institute for Tropical Medicine (BNITM) , 20359 Hamburg,","place":["Germany"]},{"name":"German Center for Infection Research (DZIF), Partner Site Hamburg\u2013L\u00fcbeck\u2013Borstel\u2013Riems , 20251 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