{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T10:25:57Z","timestamp":1770546357041,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BBSRC LIDo PhD studentship","award":["BB\/T008709\/1"],"award-info":[{"award-number":["BB\/T008709\/1"]}]},{"name":"UKRI MRC","award":["IAA2129"],"award-info":[{"award-number":["IAA2129"]}]},{"name":"UKRI MRC","award":["MR\/R026297\/1"],"award-info":[{"award-number":["MR\/R026297\/1"]}]},{"name":"UKRI MRC","award":["MR\/X005895\/1"],"award-info":[{"award-number":["MR\/X005895\/1"]}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/Y018842\/1"],"award-info":[{"award-number":["EP\/Y018842\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Malaria, caused by Plasmodium parasites, imposes a significant public health burden. While Plasmodium falciparum remains the primary target of elimination strategies due to its high mortality rate, lesser-known species such as P. malariae, P. vivax, and P. knowlesi continue to contribute to substantial human morbidity. Genomic approaches, including whole-genome sequencing, offer powerful tools for understanding the biology, transmission, and emerging drug resistance of these neglected Plasmodium species. However, there is an urgent need for informatic tools to summarize and visualize the high-dimensional and complex genomic data generated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We developed Malaria-GENOMAP, a user-friendly web-based tool, which integrates genomic variant data, such as allele frequencies, with geographical maps and chromosome-wide to gene views for in-depth exploration. The tool includes variation from P. knowlesi (n\u2009=\u2009139), P. malariae (n\u2009=\u2009158), P. ovale curtisi (n\u2009=\u200936), P. ovale wallikeri (n\u2009=\u200947), P. simium (n\u2009=\u200938), and P. vivax (n\u2009=\u20091359). It enables the investigation of population structure, geographic associations of mutations, and putative drug resistance markers, offering valuable insights for malaria control efforts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Malaria-GENOMAP is available online at https:\/\/genomics.lshtm.ac.uk\/malaria-genomaps.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag016","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T12:38:59Z","timestamp":1768048739000},"source":"Crossref","is-referenced-by-count":0,"title":["Malaria-GENOMAP: a web-based tool for exploring genomic variation of malaria parasites"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5860-0182","authenticated-orcid":false,"given":"Joseph","family":"Thorpe","sequence":"first","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-6911","authenticated-orcid":false,"given":"Nina","family":"Billows","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle C","family":"Ngwana-Joseph","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Nolder","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]},{"name":"UKHSA Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1592-6407","authenticated-orcid":false,"given":"Colin J","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]},{"name":"UKHSA Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine , Keppel St , London, WC1E 7HT,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Hong Ngoc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Molecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology , Hanoi, 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Huong Binh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Molecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology , Hanoi, 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang Thieu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Molecular Biology Department, Parasitology and Entomology, Vietnam National Institute of Malariology , Hanoi, 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamille G","family":"Dombrowski","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo , Av. 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