{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T18:38:42Z","timestamp":1770316722913,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022719","name":"Darwin Trust of Edinburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022719","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004052","name":"KAUST","doi-asserted-by":"publisher","award":["BAS\/1\/1108\u201301-01"],"award-info":[{"award-number":["BAS\/1\/1108\u201301-01"]}],"id":[{"id":"10.13039\/501100004052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UKRI Future Leaders Fellowship","award":["MR\/V027204\/1"],"award-info":[{"award-number":["MR\/V027204\/1"]}]},{"name":"UKRI Future Leaders Fellowship","award":["FCC\/1\/5932\u201301-03"],"award-info":[{"award-number":["FCC\/1\/5932\u201301-03"]}]},{"name":"KAUST Center of Excellence for Smart Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Chemical genomics is a powerful high-throughput approach to systematically link phenotypes to genotypes. However, the vast datasets generated remain challenging to explore due to the lack of integrated, interactive tools for visualization and analysis. Existing workflows often require multiple independent software tools, limiting data accessibility and collaboration. Therefore, we created a user-friendly platform that enables efficient exploration and sharing of chemical genomics data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We developed ChemGenXplore, a web-based Shiny application designed to streamline the visualization and analysis of chemical genomic screens. It offers two primary functionalities: one for exploring pre-implemented datasets and another for analysing user-uploaded datasets. ChemGenXplore enables users to visualize phenotypic profiles, assess gene\u2013gene and condition\u2013condition correlations, perform GO and KEGG enrichment analysis, and generate customizable, interactive heatmaps. To further support collaborative research, ChemGenXplore also facilitates the comparative analysis of chemical genomic and other omics datasets. By consolidating these features into a single interactive and accessible tool, ChemGenXplore facilitates data sharing, enhances reproducibility, and promotes collaboration within the research community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>ChemGenXplore is freely accessible as a web application at https:\/\/chemgenxplore.kaust.edu.sa\/. Source code and documentation, including instructions for local installation, are provided on GitHub (https:\/\/github.com\/Hudaahmadd\/ChemGenXplore). A Docker image is also available on DockerHub (https:\/\/hub.docker.com\/r\/hudaahmad\/chemgenxplore) to ensure reproducibility and simplify installation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag021","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T12:32:09Z","timestamp":1768307529000},"source":"Crossref","is-referenced-by-count":0,"title":["ChemGenXplore: an interactive tool for exploring and analysing chemical genomic data"],"prefix":"10.1093","volume":"42","author":[{"given":"Huda","family":"Ahmad","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Infection and School of Biosciences , University of Birmingham , Birmingham, B15 2TT,","place":["United Kingdom"]}]},{"given":"Hannah M","family":"Doherty","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection and School of Biosciences , University of Birmingham , Birmingham, B15 2TT,","place":["United 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School of Biosciences , University of Birmingham , Birmingham, B15 2TT,","place":["United Kingdom"]}]},{"given":"Danesh","family":"Moradigaravand","sequence":"additional","affiliation":[{"name":"Laboratory of Infectious Disease Epidemiology, KAUST Center of Excellence for Smart Health and Biological and Environmental Science and Engineering (BESE) Division , King Abdullah University of Science and Technology (KAUST) , Thuwal 23955-6900,","place":["Kingdom of Saudi Arabia"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4682-1037","authenticated-orcid":false,"given":"Manuel","family":"Banzhaf","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Infection and School of Biosciences , University of Birmingham , Birmingham, B15 2TT,","place":["United Kingdom"]},{"name":"Newcastle University Biosciences Institute, Faculty of Medical Sciences , Newcastle University , Newcastle upon Tyne, NE2 4HH,","place":["United 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