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We highlight Syotti\u2019s ability to perform simultaneous large-scale designs and its effectiveness as a reliable alternative when existing tools such as CATCH are not well suited to the problem setting.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btag100","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:31:57Z","timestamp":1772602317000},"source":"Crossref","is-referenced-by-count":0,"title":["Response to: \u201cbest practices when benchmarking CATCH for the design of genome enrichment probes\u201d"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-9225","authenticated-orcid":false,"given":"Jarno N","family":"Alanko","sequence":"first","affiliation":[{"name":"Department of Computer Science, University of Helsinki , 00014 Helsinki,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-5510","authenticated-orcid":false,"given":"Ilya 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