{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:33:58Z","timestamp":1777239238073,"version":"3.51.4"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>MirtronDB provides a comprehensive and up-to-date resource for advancing mirtron research within RNA biology. Therefore, maintaining a specialized and continuously updated resource for mirtrons is essential to support ongoing discoveries and to serve as a key reference for researchers investigating the roles of mirtrons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Here, we present mirtronDB 2.0, an enhanced version that expands both content and functionality. This version integrates mirtron data published between 2017 and 2025, increasing the number of documented mirtrons across various species. In addition, it incorporates newly predicted mirtrons identified through a robust pipeline that combines advanced bioinformatics and machine learning approaches, with specific coverage of six mammalian species. We have introduced new website features, including an interactive dashboard to enhance usability and facilitate intuitive data exploration. These rigorous updates consolidate mirtronDB as a key resource for mirtron to the RNA biology community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>mirtronDB can be found under http:\/\/mirtrondb.cp.utfpr.edu.br\/. The complete content of Database 2.0 and the source code for the analyses are also freely available in the FigShare repository: https:\/\/figshare.com\/articles\/dataset\/MirtronDB_version2\/29344775.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag114","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:47:09Z","timestamp":1772714829000},"source":"Crossref","is-referenced-by-count":0,"title":["mirtronDB 2.0: enhanced database with novel mirtron discoveries"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-1132","authenticated-orcid":false,"given":"Fabiana Rodrigues","family":"de Goes","sequence":"first","affiliation":[{"name":"Rosalind Franklin Institute, Harwell Science and Innovation Campus , Didcot, OX11 0QS,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8444-1898","authenticated-orcid":false,"given":"Matheus Fujimura","family":"Soares","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, S\u00e3o Paulo State University (UNESP) , Ara\u00e7atuba, 16050-680,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0331-3435","authenticated-orcid":false,"given":"Vitor","family":"Gregorio","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Federal University of Technology-Parana , Cornelio Procopio, 86300-000,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-6486","authenticated-orcid":false,"given":"Bruno Thiago de Lima","family":"Nichio","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Federal University of Technology-Parana , Cornelio Procopio, 86300-000,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0674","authenticated-orcid":false,"given":"Alisson Gaspar","family":"Chiquitto","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Federal University of Technology-Parana , Cornelio Procopio, 86300-000,","place":["Brazil"]},{"name":"Federal Institute of Education, Science and Technology of Mato Grosso do Sul , Navirai, 79947-334,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-3712","authenticated-orcid":false,"given":"Flavia Lombardi","family":"Lopes","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, S\u00e3o Paulo State University (UNESP) , Ara\u00e7atuba, 16050-680,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-1415","authenticated-orcid":false,"given":"Mark","family":"Basham","sequence":"additional","affiliation":[{"name":"Rosalind Franklin Institute, Harwell Science and Innovation Campus , Didcot, OX11 0QS,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1290-0853","authenticated-orcid":false,"given":"Douglas Silva","family":"Domingues","sequence":"additional","affiliation":[{"name":"Department of Genetics, \u201cLuiz de Queiroz\u201d College of Agriculture, University of S\u00e3o Paulo , Piracicaba, S\u00e3o Paulo, 13418-900,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-0582","authenticated-orcid":false,"given":"Alexandre Rossi","family":"Paschoal","sequence":"additional","affiliation":[{"name":"Rosalind Franklin 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