{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:51:56Z","timestamp":1774727516022,"version":"3.50.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon"},{"name":"Marie Sklodowska-Curie grant","award":["101118915"],"award-info":[{"award-number":["101118915"]}]},{"name":"Marie Sklodowska-Curie grant","award":["PID2019-109592GBI00"],"award-info":[{"award-number":["PID2019-109592GBI00"]}]},{"name":"Marie Sklodowska-Curie grant","award":["MICIU\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MICIU\/AEI\/10.13039\/501100011033"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades (MICIU)\u2014Agencia Estatal de Investigaci\u00f3n"},{"name":"Conselleria d\u2019Innovaci\u00f3"},{"name":"Universitats, Ci\u00e8ncia i Societat Digital from the Generalitat Valenciana","award":["CIAICO\/2021\/180"],"award-info":[{"award-number":["CIAICO\/2021\/180"]}]},{"name":"European Union\u2019s Horizon 2020","award":["101034324"],"award-info":[{"award-number":["101034324"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Mixtum is a Python-based code that estimates ancestry contributions in a process of two-way admixture based on bi-allelic genotype data. The outcomes of Mixtum come from the geometric interpretation of the f-statistics formalism. Designed with user-friendliness as a priority, Mixtum allows to interactively handle a menu of user-supplied populations to build different mixture models in conjunction with the set of auxiliary populations required by the framework. The results are presented graphically and numerically. Importantly, Mixtum provides a novel index (an angle) that assesses the quality of the ancestral reconstruction of the model under scrutiny. The use and interpretation of the outcomes of Mixtum are explained and illustrated with case studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The open source code is available on GitHub at https:\/\/github.com\/jmcastelo\/mixtum and on Zenodo at https:\/\/doi.org\/10.5281\/zenodo.17789375. Mixtum is implemented in Python and runs on Linux, Windows and macOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag123","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:32:55Z","timestamp":1773145975000},"source":"Crossref","is-referenced-by-count":0,"title":["Mixtum: a graphical tool for two-way admixture analysis in population genetics based on\n                    <i>f<\/i>\n                    -statistics"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3435-0273","authenticated-orcid":false,"given":"Jos\u00e9-Mar\u00eda","family":"Castelo","sequence":"first","affiliation":[{"name":"Instituto de Ciencia de los Materiales (ICMUV), Universitat de Val\u00e8ncia , Paterna 46980,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1682-5798","authenticated-orcid":false,"given":"Jos\u00e9-Angel","family":"Oteo","sequence":"additional","affiliation":[{"name":"Departament de F\u00edsica Te\u00f2rica, Universitat de Val\u00e8ncia , Burjassot 46100,","place":["Spain"]},{"name":"Institute for Integrative Systems Biology I2SYSBIO , Paterna 46980,","place":["Spain"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0957-4014","authenticated-orcid":false,"given":"Gonzalo","family":"Oteo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Ambientale, Sapienza Universit\u00e0 di Roma , Rome 00185,","place":["Italy"]},{"name":"Centre for Palaeogenetics, Stockholm University , Stockholm SE-106 91,","place":["Sweden"]},{"name":"Department of Archaeology and Classical Studies, Stockholm University , Stockholm SE-106 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