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This limitation is particularly critical in cancer, where transcriptional programs are inherently tissue-specific. To address this gap, we developed GRNContext, an interactive web platform designed for the visualization, exploration, and comparative analysis of gene regulatory networks contextualized across 33 cancer types from The Cancer Genome Atlas (TCGA). Our approach uses the TFLink human reference GRN as a starting point and integrates TCGA transcriptomic profiles to infer cancer-specific regulatory activity. Regulatory relevance was assessed using complementary machine learning and statistical methods, which were unified into a consensus score to prioritize and filter the most relevant candidate regulators for each target gene. By providing both curated context-specific GRNs and a user-friendly platform, GRNContext constitutes a comprehensive and accessible resource that supports mechanistic investigations, hypothesis generation, and translational research focused on transcriptional regulation in cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and Implementation<\/jats:title>\n                    <jats:p>GRNContext is supported by all major browsers and freely available on the web at https:\/\/apps.cienciavida.org\/grncontext. It is implemented as a client-server web application featuring a FastAPI backend and a React frontend utilizing Cytoscape.js for interactive network visualization, all containerized via Docker for cross-platform compatibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag389","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:22:19Z","timestamp":1781500939000},"source":"Crossref","is-referenced-by-count":0,"title":["GRNContext: an interactive web platform for contextualized gene regulatory networks visualization across human cancers"],"prefix":"10.1093","volume":"42","author":[{"given":"Ignacio","family":"Pezoa-Soto","sequence":"first","affiliation":[{"name":"Centro Basal Ciencia & Vida , Avenida del Valle Norte 725 , Santiago, 8580702,","place":["Chile"]},{"name":"Centro de Biolog\u00eda Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebasti\u00e1n , Avenida del Valle Norte 725 , Santiago, 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Miguel de Unamuno , Salamanca, 37007,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL) , Paseo San Vicente 58-182 , Salamanca, 37007,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Lladser","sequence":"additional","affiliation":[{"name":"Centro Basal Ciencia & Vida , Avenida del Valle Norte 725 , Santiago, 8580702,","place":["Chile"]},{"name":"Facultad de Medicina, Universidad San Sebasti\u00e1n , Lota 2465 , Santiago, 7510157,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Varas-Godoy","sequence":"additional","affiliation":[{"name":"Centro Basal Ciencia & Vida , Avenida del Valle Norte 725 , Santiago, 8580702,","place":["Chile"]},{"name":"Centro de Biolog\u00eda Celular y Biomedicina (CEBICEM), Facultad de Ciencias, Universidad San Sebasti\u00e1n , Avenida del Valle Norte 725 , Santiago, 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