{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:07:44Z","timestamp":1784837264028,"version":"3.55.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM128932"],"award-info":[{"award-number":["R35GM128932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Ancestral Recombination Graphs (ARGs) provide a comprehensive representation of genetic ancestry and underpin analyses of natural selection, disease association, and population history. However, existing visualization tools are limited in scalability and interactivity, making ARGs difficult to explore at biobank scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We introduce Lorax, a GPU-accelerated, web-native platform for real-time visualization of population-scale ARGs. Lorax integrates genomic position, coalescent time, local genealogy, and metadata, enabling interactive exploration of ancestry and variant inheritance in biobank-scale datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Lorax is freely available as a live demo at https:\/\/lorax.ucsc.edu\/ and as a Python package \u201clorax-arg\u201d on PyPI. The source code and documentation are available on GitHub at https:\/\/github.com\/pratikkatte\/lorax.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag458","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:48:29Z","timestamp":1782388109000},"source":"Crossref","is-referenced-by-count":0,"title":["Interactive exploration of biobank-scale ancestral recombination graphs with Lorax"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-1675","authenticated-orcid":false,"given":"Pratik","family":"Katte","sequence":"first","affiliation":[{"name":"Department of Biomolecular Engineering, UC Santa Cruz , Santa Cruz, CA 95060,","place":["United States"]},{"name":"Genomics Institute, UC Santa Cruz , Santa Cruz, CA 95060,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Corbett-Detig","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Engineering, UC Santa Cruz , Santa Cruz, CA 95060,","place":["United States"]},{"name":"Genomics Institute, UC Santa Cruz , Santa Cruz, CA 95060,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"2026072315263593600_btag458-B1","doi-asserted-by":"crossref","first-page":"1iyab229","DOI":"10.1093\/genetics\/iyab229","article-title":"Efficient ancestry and mutation simulation with msprime 1.0","volume":"220","author":"Baumdicker","year":"2022","journal-title":"Genetics"},{"key":"2026072315263593600_btag458-B2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/421051","article-title":"Genetic signatures of strong recent positive selection at the lactase gene","volume":"74","author":"Bersaglieri","year":"2004","journal-title":"Am J Hum Genet"},{"key":"2026072315263593600_btag458-B3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1126\/science.aaw2090","article-title":"Genomic architecture and introgression shape a butterfly radiation","volume":"366","author":"Edelman","year":"2019","journal-title":"Science"},{"key":"2026072315263593600_btag458-B4","doi-asserted-by":"crossref","first-page":"e1008895","DOI":"10.1371\/journal.pgen.1008895","article-title":"Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph","volume":"16","author":"Hubisz","year":"2020","journal-title":"PLoS Genet"},{"key":"2026072315263593600_btag458-B5","author":"Jeffery","year":"2026"},{"key":"2026072315263593600_btag458-B6","doi-asserted-by":"crossref","first-page":"vbaf302","DOI":"10.1093\/bioadv\/vbaf302","article-title":"Tskit_arg_visualizer: interactive plotting of ancestral recombination graphs","volume":"5","author":"Kitchens","year":"2025","journal-title":"Bioinform Adv"},{"key":"2026072315263593600_btag458-B7","doi-asserted-by":"crossref","first-page":"e1011110","DOI":"10.1371\/journal.pgen.1011110","article-title":"The era of the ARG: an introduction to ancestral recombination graphs and their significance in empirical evolutionary genomics","volume":"20","author":"Lewanski","year":"2024","journal-title":"PLoS Genet"},{"key":"2026072315263593600_btag458-B8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41576-024-00772-4","article-title":"Inference and applications of ancestral recombination graphs","volume":"26","author":"Nielsen","year":"2025","journal-title":"Nat Rev Genet"},{"key":"2026072315263593600_btag458-B9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/s41588-019-0484-x","article-title":"A method for genome-wide genealogy estimation for thousands of samples","volume":"51","author":"Speidel","year":"2019","journal-title":"Nat Genet"},{"key":"2026072315263593600_btag458-B10","author":"Talbot","year":"2025"},{"key":"2026072315263593600_btag458-B11","doi-asserted-by":"crossref","first-page":"eabi8264","DOI":"10.1126\/science.abi8264","article-title":"A unified genealogy of modern and ancient genomes","volume":"375","author":"Wohns","year":"2022","journal-title":"Science"},{"key":"2026072315263593600_btag458-B12","author":"Zhan","year":"2023"},{"key":"2026072315263593600_btag458-B13","author":"Zhang","year":"2021"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btag458\/68641204\/btag458.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/42\/7\/btag458\/68641204\/btag458.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/42\/7\/btag458\/68641204\/btag458.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:26:42Z","timestamp":1784834802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btag458\/8721294"}},"subtitle":[],"editor":[{"given":"Russell","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btag458","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,27]]},"article-number":"btag458"}}