{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:33:42Z","timestamp":1773272022095,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The study of genetic regulatory networks has received a major impetus from the recent development of experimental techniques allowing the measurement of patterns of gene expression in a massively parallel way. This experimental progress calls for the development of appropriate computer tools for the modeling and simulation of gene regulation processes.<\/jats:p>\n               <jats:p>Results: We present Genetic Network Analyzer (GNA), a computer tool for the modeling and simulation of genetic regulatory networks. The tool is based on a qualitative simulation method that employs coarse-grained models of regulatory networks. The use of GNA is illustrated by a case study of the network of genes and interactions regulating the initiation of sporulation in Bacillus subtilis.<\/jats:p>\n               <jats:p>Availability: GNA and the model of the sporulation network are available at http:\/\/www-helix.inrialpes.fr\/gna<\/jats:p>\n               <jats:p>Contact: Hidde.de-Jong@inrialpes.fr<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btf851","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T19:58:00Z","timestamp":1045079880000},"page":"336-344","source":"Crossref","is-referenced-by-count":193,"title":["Genetic Network Analyzer: qualitative simulation of\ngenetic regulatory networks"],"prefix":"10.1093","volume":"19","author":[{"given":"Hidde","family":"de Jong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Geiselmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,2,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/3\/336\/48903802\/bioinformatics_19_3_336.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/3\/336\/48903802\/bioinformatics_19_3_336.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:33:46Z","timestamp":1674660826000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/3\/336\/258016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,2,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btf851","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,2,12]]},"published":{"date-parts":[[2003,2,12]]}}}