{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T15:57:19Z","timestamp":1719071839966},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Numerical output of spotted microarrays displays censoring of pixel intensities at some software dependent threshold. This reduces the quality of gene expression data, because it seriously violates the linearity of expression with respect to signal intensity. Statistical methods based on typically available spot summaries together with some parametric assumptions can suggest ways to correct for this defect<\/jats:p>\n               <jats:p>Results: A maximum likelihood approach is suggested together with a sensible approximation to the joint density of the mean, median and variance\u2014which are typically available to the biological end-user. The method \u2018corrects\u2019 the gene expression values for pixel censoring. A by-product of our approach is a comparison between several two-parameter models for pixel intensity values. It suggests that pixels separated by one or two other pixels can be considered independent draws from a Lognormal or a Gamma distribution<\/jats:p>\n               <jats:p>Availability: The R\/S-Plus code is available at http:\/\/www.stats.gla.ac.uk\/~microarray\/software<\/jats:p>\n               <jats:p>Contact: ernst@stats.gla.ac.uk<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg003","type":"journal-article","created":{"date-parts":[[2003,6,11]],"date-time":"2003-06-11T20:12:00Z","timestamp":1055362320000},"page":"1055-1060","source":"Crossref","is-referenced-by-count":15,"title":["Statistical adjustment of signal censoring in gene expression experiments"],"prefix":"10.1093","volume":"19","author":[{"given":"Ernst","family":"Wit","sequence":"first","affiliation":[{"name":"Department of Statistics, University of Glasgow, Glasgow G12 8QW, UK"}]},{"given":"John","family":"McClure","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Glasgow, Glasgow G12 8QW, UK"}]}],"member":"286","published-online":{"date-parts":[[2003,6,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/9\/1055\/48904140\/bioinformatics_19_9_1055.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/9\/1055\/48904140\/bioinformatics_19_9_1055.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:51:51Z","timestamp":1674665511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/9\/1055\/284963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,12]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,6,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg003","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,6,12]]},"published":{"date-parts":[[2003,6,12]]}}}