{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:41:55Z","timestamp":1772818915414,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: PCMA (profile consistency multiple sequence alignment) is a progressive multiple sequence alignment program that combines two different alignment strategies. Highly similar sequences are aligned in a fast way as in ClustalW, forming pre-aligned groups. The T-Coffee strategy is applied to align the relatively divergent groups based on profile\u2013profile comparison and consistency. The scoring function for local alignments of pre-aligned groups is based on a novel profile\u2013profile comparison method that is a generalization of the PSI-BLAST approach to profile\u2013sequence comparison. PCMA balances speed and accuracy in a flexible way and is suitable for aligning large numbers of sequences.<\/jats:p>\n               <jats:p>Availability: PCMA is freely available for non-commercial use. Pre-compiled versions for several platforms can be downloaded from ftp:\/\/iole.swmed.edu\/pub\/PCMA\/<\/jats:p>\n               <jats:p>Contact: jpei@mednet.swmed.edugrishin@chop.swmed.edu<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg008","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T19:58:00Z","timestamp":1045079880000},"page":"427-428","source":"Crossref","is-referenced-by-count":144,"title":["PCMA: fast and accurate multiple sequence alignment based on profile consistency"],"prefix":"10.1093","volume":"19","author":[{"given":"Jimin","family":"Pei","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruslan","family":"Sadreyev","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick V.","family":"Grishin","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, and Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9050, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,2,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/3\/427\/48903808\/bioinformatics_19_3_427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/3\/427\/48903808\/bioinformatics_19_3_427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:44:51Z","timestamp":1674661491000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/3\/427\/258412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,2,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg008","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,2,12]]},"published":{"date-parts":[[2003,2,12]]}}}