{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T17:07:01Z","timestamp":1742404021458},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Multiple sequence alignments are essential tools for establishing the homology relations between proteins. Essential amino acids for the function and\/or the structure are generally conserved, thus providing key arguments to help in protein characterization. However for distant proteins, it is more difficult to establish, in a reliable way, the homology relations that may exist between them. In this article, we show that secondary structure prediction is a valuable way to validate protein families at low identity rate.<\/jats:p>\n               <jats:p>Results: We show that the analysis of the secondary structures compatibility is a reliable way to discard non-related proteins in low identity multiple alignment.<\/jats:p>\n               <jats:p>Availability: This validation is possible through our NPS@ server (http:\/\/npsa-pbil.ibcp.fr)<\/jats:p>\n               <jats:p>Contact: g.deleage@ibcp.fr<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg016","type":"journal-article","created":{"date-parts":[[2003,2,28]],"date-time":"2003-02-28T19:57:40Z","timestamp":1046462260000},"page":"506-512","source":"Crossref","is-referenced-by-count":19,"title":["Detection of unrelated proteins in sequences multiple alignments by using \npredicted secondary structures"],"prefix":"10.1093","volume":"19","author":[{"given":"Mounir","family":"Errami","sequence":"first","affiliation":[{"name":"P\u00f4le de BioInformatique Lyonnais, Institut de Biologie et de Chimie des Prot\u00e9ines, Centre National de la Recherche Scientifique, UMR 5086, 69367 Lyon CEDEX 07, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Geourjon","sequence":"additional","affiliation":[{"name":"P\u00f4le de BioInformatique Lyonnais, Institut de Biologie et de Chimie des Prot\u00e9ines, Centre National de la Recherche Scientifique, UMR 5086, 69367 Lyon CEDEX 07, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Del\u00e9age","sequence":"additional","affiliation":[{"name":"P\u00f4le de BioInformatique Lyonnais, Institut de Biologie et de Chimie des Prot\u00e9ines, Centre National de la Recherche Scientifique, UMR 5086, 69367 Lyon CEDEX 07, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/4\/506\/48903906\/bioinformatics_19_4_506.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/4\/506\/48903906\/bioinformatics_19_4_506.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:43:14Z","timestamp":1674664994000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/4\/506\/218630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg016","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,3,1]]},"published":{"date-parts":[[2003,3,1]]}}}