{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:37:51Z","timestamp":1776335871205,"version":"3.51.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Genome projects for many prokaryotic and eukaryotic species have been completed and more new genome projects are being underway currently. The availability of a large number of genomic sequences for researchers creates a need to find graphic tools to study genomes in a perceivable form. The Z curve is one of such tools available for visualizing genomes. The Z curve is a unique three-dimensional curve representation for a given DNA sequence in the sense that each can be uniquely reconstructed given the other. The Z curve database for more than 1000 genomes have been established here.<\/jats:p>\n               <jats:p>Results: The database contains the Z curves for archaea, bacteria, eukaryota, organelles, phages, plasmids, viroids and viruses, whose genomic sequences are currently available. All the 3-dimensional Z curves and their three component curves are stored in the database. The applications of the Z curve database on comparative genomics, gene prediction, computation of G+C content with a windowless technique, prediction of replication origins and terminations of bacterial and archaeal genomes and study of local deviations from the Chargaff Parity Rule 2 etc. are presented in detail. The Z curve database reported here is a treasure trove in which biologists could find useful biological knowledge.<\/jats:p>\n               <jats:p>Availability: The Z curve database is freely available at the website: http:\/\/tubic.tju.edu.cn\/zcurve\/<\/jats:p>\n               <jats:p>Contact: ctzhang@tju.edu.cn<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg041","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T19:31:39Z","timestamp":1048275099000},"page":"593-599","source":"Crossref","is-referenced-by-count":107,"title":["The Z curve database: a graphic representation of genome sequences"],"prefix":"10.1093","volume":"19","author":[{"given":"Chun-Ting","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Ren","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Hong-Yu","family":"Ou","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2003,3,22]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/5\/593\/48904224\/bioinformatics_19_5_593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/5\/593\/48904224\/bioinformatics_19_5_593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:45:12Z","timestamp":1674665112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/5\/593\/239456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,22]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,3,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg041","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,3,22]]},"published":{"date-parts":[[2003,3,22]]}}}