{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:18:56Z","timestamp":1767845936961,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Recent screening techniques have made large amounts of protein\u2013protein interaction data available, from which biologically important information such as the function of uncharacterized proteins, the existence of novel protein complexes, and novel signal-transduction pathways can be discovered. However, experimental data on protein interactions contain many false positives, making these discoveries difficult. Therefore computational methods of assessing the reliability of each candidate protein\u2013protein interaction are urgently needed.<\/jats:p>\n               <jats:p>Results: We developed a new \u2018interaction generality\u2019 measure (IG2) to assess the reliability of protein\u2013protein interactions using only the topological properties of their interaction-network structure. Using yeast protein\u2013protein interaction data, we showed that reliable protein\u2013protein interactions had significantly lower IG2 values than less-reliable interactions, suggesting that IG2 values can be used to evaluate and filter interaction data to enable the construction of reliable protein\u2013protein interaction networks.<\/jats:p>\n               <jats:p>Availability: The protein\u2013protein interaction data used in this study along with the associated IG2 values are available at http:\/\/genome.gsc.riken.go.jp.<\/jats:p>\n               <jats:p>Contact: rgscerg@gsc.riken.go.jp<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>\n               <jats:p>\u2020 Present address: Institute for Advanced Biosciences, Keio University, 14-1 Baba-cho, Tsuruoka, Yamagata 997-0035, Japan.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg070","type":"journal-article","created":{"date-parts":[[2003,4,11]],"date-time":"2003-04-11T18:03:47Z","timestamp":1050084227000},"page":"756-763","source":"Crossref","is-referenced-by-count":89,"title":["Construction of reliable protein\u2013protein interaction networks\nwith a new interaction generality measure"],"prefix":"10.1093","volume":"19","author":[{"given":"Rintaro","family":"Saito","sequence":"first","affiliation":[{"name":"Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 and Genome Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"}]},{"given":"Harukazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 and Genome Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"}]},{"given":"Yoshihide","family":"Hayashizaki","sequence":"additional","affiliation":[{"name":"Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045 and Genome Science Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan"}]}],"member":"286","published-online":{"date-parts":[[2003,4,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/6\/756\/48903862\/bioinformatics_19_6_756.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/6\/756\/48903862\/bioinformatics_19_6_756.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:02:06Z","timestamp":1674662526000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/6\/756\/234485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,12]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,4,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg070","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,4,12]]},"published":{"date-parts":[[2003,4,12]]}}}