{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:05:11Z","timestamp":1773288311659,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Chemical carcinogenicity is of primary interest, because it drives much of the current regulatory actions regarding new and existing chemicals, and its experimental determination involves time-consuming and expensive animal testing. Both academia and private companies are actively trying to develop SAR and QSAR models. This paper reviews the new Predictive Toxicology Challenge (PTC) results, by putting them into the context of previous attempts.<\/jats:p>\n               <jats:p>Results: A marked dependency of the prediction ability of the different algorithms on the training sets was observed, pointing to a still insufficient coverage of the chemical carcinogens \u2018universe\u2019. A theoretical treatment of the possible developments of the Artificial Intelligence approaches is sketched.<\/jats:p>\n               <jats:p>Contact: rbenigni@iss.it<\/jats:p>\n               <jats:p>* To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg099","type":"journal-article","created":{"date-parts":[[2003,6,30]],"date-time":"2003-06-30T23:09:17Z","timestamp":1057014557000},"page":"1194-1200","source":"Crossref","is-referenced-by-count":54,"title":["Putting the Predictive Toxicology Challenge\ninto perspective: reflections on the results"],"prefix":"10.1093","volume":"19","author":[{"given":"Romualdo","family":"Benigni","sequence":"first","affiliation":[{"name":"Laboratory of Comparative Toxicology and Ecotoxicology, \u2018Istituto Superiore di Sanita\u2019, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Laboratory of Comparative Toxicology and Ecotoxicology, \u2018Istituto Superiore di Sanita\u2019, Viale Regina Elena 299, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,1]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/10\/1194\/48903840\/bioinformatics_19_10_1194.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/10\/1194\/48903840\/bioinformatics_19_10_1194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T15:43:56Z","timestamp":1674661436000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/10\/1194\/184200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg099","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,7,1]]},"published":{"date-parts":[[2003,7,1]]}}}