{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T19:34:43Z","timestamp":1697225683274},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The Protein Data Bank contains a large amount of proteins that have been solved with small ligands bound to them. This constitutes a rich source of information for the study of the specific requirements of protein sites to bind small molecules with a favorable free energy. The specific atomic composition and three-dimensional geometric restraints of protein binding sites for different ligands could be easily obtained from there. The development of accurate binding site descriptors in proteins constitutes a valuable tool to assist in the large-scale prediction and annotation of protein function in whole genomes. In this work, an integrated database containing some processed and calculated protein\/ligand information is described. It is expected that this database will constitute a useful tool for people working in the prediction of protein function from its structure. The database is accessible from the Internet through a web server located at: http:\/\/protein.bio.puc.cl<\/jats:p>\n               <jats:p>Contact: fmelo@genes.bio.puc.cl<\/jats:p>\n               <jats:p>Keywords: Ligands, function, structure, proteins, binding sites, conformational analysis<\/jats:p>\n               <jats:p>*To whom correspondence should be addressed.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg1034","type":"journal-article","created":{"date-parts":[[2003,7,10]],"date-time":"2003-07-10T23:49:03Z","timestamp":1057880943000},"page":"i250-i251","source":"Crossref","is-referenced-by-count":1,"title":["A tool to assist the study of specific\nfeatures at protein binding sites"],"prefix":"10.1093","volume":"19","author":[{"given":"V\u00edctor","family":"Santander","sequence":"first","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile, Departmento Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Alameda 340, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Portales","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile, Departmento Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Alameda 340, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Melo","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile, Departmento Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Alameda 340, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,7,3]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/suppl_1\/i250\/228096","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/suppl_1\/i250\/228096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:46:18Z","timestamp":1674672378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/suppl_1\/i250\/228096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,3]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2003,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg1034","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,7,3]]},"published":{"date-parts":[[2003,7,3]]}}}