{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:57:23Z","timestamp":1773856643224,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this paper we propose a new method for recognition of prokaryotic promoter regions with startpoints of transcription. The method is based on Sequence Alignment Kernel, a function reflecting the quantitative measure of match between two sequences. This kernel function is further used in Dual SVM, which performs the recognition.<\/jats:p>\n               <jats:p>Several recognition methods have been trained and tested on positive data set, consisting of 669 \u03c370-promoter regions with known transcription startpoints of Escherichia coli and two negative data sets of 709 examples each, taken from coding and non-coding regions of the same genome. The results show that our method performs well and achieves 16.5% average error rate on positive &amp; coding negative data and 18.6% average error rate on positive &amp; non-coding negative data.<\/jats:p>\n               <jats:p>Availability:The demo version of our method is accessible from our website http:\/\/mendel.cs.rhul.ac.uk\/<\/jats:p>","DOI":"10.1093\/bioinformatics\/btg265","type":"journal-article","created":{"date-parts":[[2003,10,10]],"date-time":"2003-10-10T22:56:01Z","timestamp":1065826561000},"page":"1964-1971","source":"Crossref","is-referenced-by-count":111,"title":["Sequence alignment kernel for recognition of promoter regions"],"prefix":"10.1093","volume":"19","author":[{"given":"Leo","family":"Gordon","sequence":"first","affiliation":[]},{"given":"Alexey Ya.","family":"Chervonenkis","sequence":"additional","affiliation":[]},{"given":"Alex J.","family":"Gammerman","sequence":"additional","affiliation":[]},{"given":"Ilham A.","family":"Shahmuradov","sequence":"additional","affiliation":[]},{"given":"Victor V.","family":"Solovyev","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2003,10,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/15\/1964\/48904450\/bioinformatics_19_15_1964.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/19\/15\/1964\/48904450\/bioinformatics_19_15_1964.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:24:22Z","timestamp":1674667462000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/19\/15\/1964\/231190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,12]]},"references-count":0,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2003,10,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btg265","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,10,12]]},"published":{"date-parts":[[2003,10,12]]}}}