{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:48:20Z","timestamp":1761540500028},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Information concerning endoplasmic reticulum (ER) proteins is widely dispersed and cannot be easily and rapidly processed by the biological community. We present a comprehensive database of human ER proteins, called Human ER Aper\u00e7u (Hera). The Hera database was constructed by exhaustively searching through public databases and the scientific literature for ER proteins.<\/jats:p>\n               <jats:p>Results: Hera was used for the analysis of characteristics common to all human ER proteins. Our results show that a high proportion of ER proteins (59%) have at least one transmembrane domain and display physical characteristics consistent with this observation. In addition, one-third of ER proteins contain known ER retrieval or retention signals and 70% of ER proteins contain a signal peptide or anchor. Finally, 85% of ER proteins contain at least one InterPro motif. The most abundant InterPro motifs in ER proteins represent many of the most well-characterized functions of the ER.<\/jats:p>\n               <jats:p>Availability: Hera is available at http:\/\/www.mcb.mcgill.ca\/~hera.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth010","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T21:41:06Z","timestamp":1078263666000},"page":"937-944","source":"Crossref","is-referenced-by-count":29,"title":["The Hera database and its use in the characterization of endoplasmic reticulum proteins"],"prefix":"10.1093","volume":"20","author":[{"given":"M.","family":"Scott","sequence":"first","affiliation":[]},{"given":"G.","family":"Lu","sequence":"additional","affiliation":[]},{"given":"M.","family":"Hallett","sequence":"additional","affiliation":[]},{"given":"D. Y.","family":"Thomas","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2004,1,29]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/6\/937\/48905315\/bioinformatics_20_6_937.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/6\/937\/48905315\/bioinformatics_20_6_937.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T17:59:47Z","timestamp":1674669587000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/6\/937\/233483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,29]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,4,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth010","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,4,12]]},"published":{"date-parts":[[2004,1,29]]}}}