{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:48:00Z","timestamp":1773953280485,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Whole genome duplications have played a major role in determining the structure of eukaryotic genomes. Current evidence revealing large blocks of duplicated chromatin yields new insights into the evolutionary history of species, but also presents a major challenge for researchers attempting to utilize comparative genomics techniques. Understanding the timing of duplication events relative to divergence among taxa is critical to accurate and comprehensive cross-species comparisons.<\/jats:p>\n               <jats:p>Results: We describe a large-scale approach to estimate the timing of duplication events in a phylogenetic context. The methodology has been previously utilized for analysis of Arabidopsis and Saccharomyces duplication events. This new implementation provides a more flexible and reusable framework for these analyses. Scripts written in the Python programming language drive a number of freely available bioinformatics programs, creating a no-cost tool for researchers. The usefulness of the approach is demonstrated through genome-scale analysis of Arabidopsis and Oryza (rice) duplications.<\/jats:p>\n               <jats:p>Availability: Software and documentation are freely available from http:\/\/plantgenome.agtec.uga.edu\/bioinformatics\/dating\/<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth022","type":"journal-article","created":{"date-parts":[[2004,1,20]],"date-time":"2004-01-20T21:07:58Z","timestamp":1074632878000},"page":"180-185","source":"Crossref","is-referenced-by-count":30,"title":["A comparative phylogenetic approach for dating whole genome duplication events"],"prefix":"10.1093","volume":"20","author":[{"given":"Brad A.","family":"Chapman","sequence":"first","affiliation":[]},{"given":"John E.","family":"Bowers","sequence":"additional","affiliation":[]},{"given":"Stefan R.","family":"Schulze","sequence":"additional","affiliation":[]},{"given":"Andrew H.","family":"Paterson","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2004,1,22]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/2\/180\/48905301\/bioinformatics_20_2_180.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/2\/180\/48905301\/bioinformatics_20_2_180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:46:51Z","timestamp":1674672411000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/2\/180\/205075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,22]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth022","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,1,22]]},"published":{"date-parts":[[2004,1,22]]}}}