{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:45:25Z","timestamp":1773013525595,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: A computational tool for mitochondrial systems biology has been developed as a simulation model of E-Cell2, a publicly available simulation system. The general model consists of 58 enzymatic reactions and 117 metabolites, representing the respiratory chain, the TCA cycle, the fatty acid \u03b2-oxidation and the inner-membrane transport system. It is based on previously published enzyme kinetics studies in the literature; we have successfully integrated and packaged them into a single large model. The model can be easily extended and modified so that mitochondrial biologists\/physiologists can integrate their own models and evaluate them in the context of the whole organelle metabolism.<\/jats:p>\n               <jats:p>Availability: The mitochondrial model is bundled up with E-Cell2 simulation system, which can be downloaded from http:\/\/www.e-cell.org. CD-ROMs are also available and are distributed at major conferences.<\/jats:p>\n               <jats:p>Supplementary information: All the kinetic data are available via http:\/\/www.e-cell.org<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth125","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T21:41:06Z","timestamp":1078263666000},"page":"1795-1796","source":"Crossref","is-referenced-by-count":39,"title":["A general computational model of mitochondrial metabolism in a whole organelle scale"],"prefix":"10.1093","volume":"20","author":[{"given":"Katsuyuki","family":"Yugi","sequence":"first","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Endo 5322, Fujisawa, Kanagawa, 252-8520, Japan"}]},{"given":"Masaru","family":"Tomita","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, Endo 5322, Fujisawa, Kanagawa, 252-8520, Japan"}]}],"member":"286","published-online":{"date-parts":[[2004,2,12]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/11\/1795\/48905844\/bioinformatics_20_11_1795.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/11\/1795\/48905844\/bioinformatics_20_11_1795.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:46:03Z","timestamp":1674665163000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/11\/1795\/300083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,12]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,7,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth125","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,7,22]]},"published":{"date-parts":[[2004,2,12]]}}}