{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:42:54Z","timestamp":1768077774045,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Is protein secondary structure primarily determined by local interactions between residues closely spaced along the amino acid backbone or by non-local tertiary interactions? To answer this question, we measure the entropy densities of primary and secondary structure sequences, and the local inter-sequence mutual information density.<\/jats:p>\n               <jats:p>Results: We find that the important inter-sequence interactions are short ranged, that correlations between neighboring amino acids are essentially uninformative and that only one-fourth of the total information needed to determine the secondary structure is available from local inter-sequence correlations. These observations support the view that the majority of most proteins fold via a cooperative process where secondary and tertiary structure form concurrently. Moreover, existing single-sequence secondary structure prediction algorithms are almost optimal, and we should not expect a dramatic improvement in prediction accuracy.<\/jats:p>\n               <jats:p>Availability: Both the data sets and analysis code are freely available from our Web site at http:\/\/compbio.berkeley.edu\/<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth132","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T21:41:06Z","timestamp":1078263666000},"page":"1603-1611","source":"Crossref","is-referenced-by-count":61,"title":["Protein secondary structure: entropy, correlations and prediction"],"prefix":"10.1093","volume":"20","author":[{"given":"Gavin E.","family":"Crooks","sequence":"first","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, 111 Koshland Hall No. 3102, Berkeley, CA 94720-3102, USA"}]},{"given":"Steven E.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, 111 Koshland Hall No. 3102, Berkeley, CA 94720-3102, USA"}]}],"member":"286","published-online":{"date-parts":[[2004,2,26]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/10\/1603\/48905976\/bioinformatics_20_10_1603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/10\/1603\/48905976\/bioinformatics_20_10_1603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:47:44Z","timestamp":1674665264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/10\/1603\/237316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,26]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth132","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,7,1]]},"published":{"date-parts":[[2004,2,26]]}}}