{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T22:05:58Z","timestamp":1717711558948},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The importance of a systematic methodology for the mathematical characterization of three-dimensional gene expression patterns in embryonic development.<\/jats:p>\n               <jats:p>Methods: By combining lacunarity and multiscale fractal dimension analyses with computer-based methods of three-dimensional reconstruction, it becomes possible to extract new information from in situ hybridization studies. Lacunarity and fractality are appropriate measures for the cloud-like gene activation signals in embryonic tissues. The newly introduced multiscale method provides a natural extension of the fractal dimension concept, being capable of characterizing the fractality of geometrical patterns in terms of spatial scale. This tool can be systematically applied to three-dimensional patterns of gene expression.<\/jats:p>\n               <jats:p>Results: Applications are illustrated using the three-dimensional expression patterns of the myogenic marker gene Myf5 in a series of differentiating somites of a mouse embryo.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth135","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T21:41:06Z","timestamp":1078263666000},"page":"1653-1662","source":"Crossref","is-referenced-by-count":9,"title":["Mathematical characterization of three-dimensional gene expression patterns"],"prefix":"10.1093","volume":"20","author":[{"given":"L. da F.","family":"Costa","sequence":"first","affiliation":[]},{"given":"M. S.","family":"Barbosa","sequence":"additional","affiliation":[]},{"given":"E. T. M.","family":"Manoel","sequence":"additional","affiliation":[]},{"given":"J.","family":"Streicher","sequence":"additional","affiliation":[]},{"given":"G. B.","family":"M\u00fcller","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2004,2,26]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/11\/1653\/48905792\/bioinformatics_20_11_1653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/11\/1653\/48905792\/bioinformatics_20_11_1653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:45:28Z","timestamp":1674665128000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/11\/1653\/300092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,26]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,7,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth135","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,7,22]]},"published":{"date-parts":[[2004,2,26]]}}}