{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:44:26Z","timestamp":1775583866347,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: One possible path towards understanding the biological function of a target protein is through the discovery of how it interfaces within protein\u2013protein interaction networks. The goal of this study was to create a virtual protein\u2013protein interaction model using the concepts of orthologous conservation (or interologs) to elucidate the interacting networks of a particular target protein. POINT (the prediction of interactome database) is a functional database for the prediction of the human protein\u2013protein interactome based on available orthologous interactome datasets. POINT integrates several publicly accessible databases, with emphasis placed on the extraction of a large quantity of mouse, fruit fly, worm and yeast protein\u2013protein interactions datasets from the Database of Interacting Proteins (DIP), followed by conversion of them into a predicted human interactome. In addition, protein\u2013protein interactions require both temporal synchronicity and precise spatial proximity. POINT therefore also incorporates correlated mRNA expression clusters obtained from cell cycle microarray databases and subcellular localization from Gene Ontology to further pinpoint the likelihood of biological relevance of each predicted interacting sets of protein partners.<\/jats:p>\n               <jats:p>Availability: POINT can be freely accessed at http:\/\/insilico.csie.ntu.edu.tw:9999\/point\/.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth366","type":"journal-article","created":{"date-parts":[[2004,6,25]],"date-time":"2004-06-25T00:25:10Z","timestamp":1088123110000},"page":"3273-3276","source":"Crossref","is-referenced-by-count":84,"title":["POINT: a database for the prediction of protein\u2013protein interactions based on the orthologous interactome"],"prefix":"10.1093","volume":"20","author":[{"given":"Tao-Wei","family":"Huang","sequence":"first","affiliation":[]},{"given":"An-Chi","family":"Tien","sequence":"additional","affiliation":[]},{"given":"Wen-Shien","family":"Huang","sequence":"additional","affiliation":[]},{"given":"Yuan-Chii G.","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Chin-Lin","family":"Peng","sequence":"additional","affiliation":[]},{"given":"Huei-Hun","family":"Tseng","sequence":"additional","affiliation":[]},{"given":"Cheng-Yan","family":"Kao","sequence":"additional","affiliation":[]},{"given":"Chi-Ying F.","family":"Huang","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2004,6,24]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/17\/3273\/48906479\/bioinformatics_20_17_3273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/17\/3273\/48906479\/bioinformatics_20_17_3273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:16:49Z","timestamp":1674663409000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/17\/3273\/186512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,24]]},"references-count":0,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2004,11,22]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth366","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,11,22]]},"published":{"date-parts":[[2004,6,24]]}}}