{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:05:22Z","timestamp":1761523522955},"reference-count":3,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We present SIM-plex, a genetic network simulator with a very intuitive interface in which a user can easily specify interactions as simple \u2018if-then\u2019 statements. The simulator is based on the mathematical model of Piecewise Linear Differential Equations (PLDEs). With PLDEs, genetic interactions are approximated as acting in a switch-like manner.<\/jats:p>\n               <jats:p>Availability: The Java program, examples and a tutorial are available at http:\/\/www.psb.ugent.be\/cbd\/<\/jats:p>\n               <jats:p>Contact: \u00a0{stcru,makui}@psb.ugent.be<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth478","type":"journal-article","created":{"date-parts":[[2004,8,20]],"date-time":"2004-08-20T02:54:50Z","timestamp":1092970490000},"page":"269-271","source":"Crossref","is-referenced-by-count":7,"title":["Simulating genetic networks made easy: network construction with simple building blocks"],"prefix":"10.1093","volume":"21","author":[{"given":"Steven","family":"Vercruysse","sequence":"first","affiliation":[{"name":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University Technologiepark 927, B-9052, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology (VIB), Ghent University Technologiepark 927, B-9052, Gent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,8,19]]},"reference":[{"key":"2023013107191762500_B1","unstructured":"de Jong, H., Gouz\u00e9, J.-L., Hernandez, C., Page, M., Sari, T., Geiselmann, J. 2004Qualitative simulation of genetic regulatory networks using piecewise-linear models. Bull. Math. Biol.66301\u2013340"},{"key":"2023013107191762500_B2","unstructured":"Glass, L. and Kauffman, S. 1973The logical analysis of continuous non-linear biochemical control networks. J. Theor. Biol.39103\u2013129"},{"key":"2023013107191762500_B3","doi-asserted-by":"crossref","unstructured":"Novak, B., Pataki, Z., Ciliberto, A., Tyson, J. 2001Mathematical model of the cell division cycle of fission yeast. Chaos11277\u2013286","DOI":"10.1063\/1.1345725"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/2\/269\/48961747\/bioinformatics_21_2_269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/2\/269\/48961747\/bioinformatics_21_2_269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T09:43:51Z","timestamp":1675158231000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/21\/2\/269\/186888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,19]]},"references-count":3,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth478","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,1,15]]},"published":{"date-parts":[[2004,8,19]]}}}