{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:36:20Z","timestamp":1771007780386,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We have generated the program easyLINKAGE that combines automated setup and performance of linkage analyses and simulation under an easy to handle graphical user interface for Microsoft Windows 2000\/XP and standard UNIX systems. The program package supports two-point linkage analyses (FastLink v4.1 and SPLink v1.09), multi-point linkage analyses [GENEHUNTER v2.1, GENEHUNTER-PLUS with the emendation by Kong and Cox v1.2 (allele sharing modelling)] and the simulation package SLINK v2.65, and provides genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P-values and other parameters.<\/jats:p>\n               <jats:p>Availability: \u00a0http:\/\/www.uni-wuerzburg.de\/nephrologie\/molecular_genetics\/molecular_genetics.htm<\/jats:p>\n               <jats:p>Contact: \u00a0tom.lindner@mail.uni-wuerzburg.de<\/jats:p>\n               <jats:p>Supplementary information: Supplementary information is available on the website.<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti009","type":"journal-article","created":{"date-parts":[[2004,9,7]],"date-time":"2004-09-07T07:33:02Z","timestamp":1094542382000},"page":"405-407","source":"Crossref","is-referenced-by-count":146,"title":["easyLINKAGE: a PERL script for easy and automated two-\/multi-point linkage analyses"],"prefix":"10.1093","volume":"21","author":[{"given":"Tom H.","family":"Lindner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,9,3]]},"reference":[{"key":"2023051306074091900_B1","unstructured":"Becker, A., Geiger, D., Schaffer, A.A. 1998Automatic selection of loop breakers for genetic linkage analysis. Hum. Hered.4849\u201360"},{"key":"2023051306074091900_B2","unstructured":"Cottingham, R.W., Jr, Idury, R.M., Schaffer, A.A. 1993Faster sequential genetic linkage computations. Am. J. Hum. Genet.53252\u2013263"},{"key":"2023051306074091900_B3","unstructured":"Holmans, P. 1993Asymptotic properties of affected-sib-pair linkage analysis. Am. J. Hum. Genet.52362\u2013374"},{"key":"2023051306074091900_B4","unstructured":"Holmans, P. and Clayton, D. 1995Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. Am. J. Hum. Genet.571221\u20131232"},{"key":"2023051306074091900_B5","unstructured":"Kong, A. and Cox, N.J. 1997Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet.611179\u20131188"},{"key":"2023051306074091900_B6","unstructured":"Kruglyak, L., Daly, M.J., Reeve-Daly, M.P., Lander, E.S. 1996Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet.581347\u20131363"},{"key":"2023051306074091900_B7","unstructured":"Ott, J. 1989Computer-simulation methods in human linkage analysis. Proc. Natl Acad. Sci. USA864175\u20134178"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/3\/405\/50305625\/bioinformatics_21_3_405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/3\/405\/50305625\/bioinformatics_21_3_405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T06:07:58Z","timestamp":1683958078000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/21\/3\/405\/237866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,3]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bti009","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,2,1]]},"published":{"date-parts":[[2004,9,3]]}}}