{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:22:53Z","timestamp":1777648973710,"version":"3.51.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Maximum-likelihood (ML) image refinement is a promising candidate to improve attainable resolution limits in 3D-EM. However, its large CPU requirements may prohibit application to 3D-structure optimization.<\/jats:p>\n               <jats:p>Results: We speeded up ML image refinement by reducing its search space over the alignment parameters. Application of this reduced-search approach to a cryo-EM dataset yielded practically identical results as the original approach, but in approximately one day instead of one week of CPU.<\/jats:p>\n               <jats:p>Availability: This work has been implemented in the public domain package Xmipp. Documentation and download instructions may be found at: http:\/\/www.cnb.uam.es\/~bioinfo<\/jats:p>\n               <jats:p>Contact: \u00a0carazo@cnb.uam.es<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti1140","type":"journal-article","created":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T21:33:25Z","timestamp":1128375205000},"page":"ii243-ii244","source":"Crossref","is-referenced-by-count":47,"title":["Fast maximum-likelihood refinement of electron microscopy images"],"prefix":"10.1093","volume":"21","author":[{"given":"Sjors H.W.","family":"Scheres","sequence":"first","affiliation":[{"name":"Centro Nacional de Biotecnolog\u00eda\u2014CSIC, Campus Universidad Aut\u00f3noma 28049, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikel","family":"Valle","sequence":"additional","affiliation":[{"name":"Centro Nacional de Biotecnolog\u00eda\u2014CSIC, Campus Universidad Aut\u00f3noma 28049, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Mar\u00eda","family":"Carazo","sequence":"additional","affiliation":[{"name":"Centro Nacional de Biotecnolog\u00eda\u2014CSIC, Campus Universidad Aut\u00f3noma 28049, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,9,1]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/suppl_2\/ii243\/52089156\/bioinformatics_21_suppl2_ii243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/21\/suppl_2\/ii243\/52089156\/bioinformatics_21_suppl2_ii243.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T04:01:14Z","timestamp":1697256074000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/21\/suppl_2\/ii243\/227818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":0,"journal-issue":{"issue":"suppl_2","published-print":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bti1140","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,9,1]]}}}