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Second, by considering only the number of changed genes, finer changes in expression patterns associated with the category may be ignored. Since genes generally participate in multiple networks, widespread and subtle modifications in expression patterns are at least as important as extreme increases\/decreases of a few genes.<\/jats:p><jats:p>Results: Numerical simulations confirm that incorporating continuous measures of gene expression for all measured transcripts yields detection of considerably more subtle changes. Applying continuous measures to microarray data from brains of mice injected with the Parkinsonian neurotoxin, MPTP, enables detection of changes in various biologically relevant GO terms, many of which are overlooked by discrete approaches.<\/jats:p><jats:p>Availability: Software (MATLAB) is available upon request from the authors.<\/jats:p><jats:p>Contact: \u00a0soreq@cc.huji.ac.il<\/jats:p><jats:p>Supplementary information: \u00a0www.icnc.huji.ac.il\/?GOdisv_supp_info<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti149","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T01:14:06Z","timestamp":1100826846000},"page":"1129-1137","source":"Crossref","is-referenced-by-count":49,"title":["Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression"],"prefix":"10.1093","volume":"21","author":[{"given":"Yoram","family":"Ben-Shaul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagai","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermona","family":"Soreq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,1,19]]},"reference":[{"key":"2023013107282662200_B1","doi-asserted-by":"crossref","unstructured":"Al-Shahrour, F., Diaz-Uriarte, R., Dopazo, J. 2004FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. 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