{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:26:08Z","timestamp":1760707568746},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: HTHquery is a web-based service to determine if a protein structure has a helix-turn-helix structural motif which could bind to DNA. It is based on a similarity with a set of structural templates, the accessibility of a putative structural motif and a positive electrostatic potential in the neighbourhood of the putative motif. A set of scores are computed, based on each template, using a linear predictor. From the training set used, the predictor has a true positive rate of 83.5% and a false positive rate of 0.8%. The emphasis for the website is on providing a straightforward interface which can be easily used by a bench-based scientist.<\/jats:p>\n               <jats:p>Availability: HTHquery is implemented using a set of Perl scripts and C program and can be accessed freely on the website http:\/\/www.ebi.ac.uk\/thornton-srv\/databases\/HTHquery<\/jats:p>\n               <jats:p>Contact: \u00a0Hugh.Shanahan@physics.org<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti575","type":"journal-article","created":{"date-parts":[[2005,7,20]],"date-time":"2005-07-20T00:14:37Z","timestamp":1121818477000},"page":"3679-3680","source":"Crossref","is-referenced-by-count":26,"title":["HTHquery: a method for detecting DNA-binding proteins with a helix-turn-helix structural motif"],"prefix":"10.1093","volume":"21","author":[{"given":"C.","family":"Ferrer-Costa","sequence":"first","affiliation":[]},{"given":"H. P.","family":"Shanahan","sequence":"additional","affiliation":[]},{"given":"S.","family":"Jones","sequence":"additional","affiliation":[]},{"given":"J. M.","family":"Thornton","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2005,7,19]]},"reference":[{"key":"2023060912071154000_B1","unstructured":"Beazley, D.M., Fletcher, D., Dumont, D. 1998Perl extension building with SWIG. O'Reilly Perl Conference 2.0, Aug. 17-20San Jose, CA"},{"key":"2023060912071154000_B2","unstructured":"Gudgin, M., et al. 2003Soap Version 1.2 Part 1: Messaging Framework"},{"key":"2023060912071154000_B3","unstructured":"Hubbard, S.J. and Thornton, J.M. 1993NACCESS, computer program"},{"key":"2023060912071154000_B4","doi-asserted-by":"crossref","unstructured":"Jones, S., et al. 2003Using structural motif templates to identify proteins with dna binding function. 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