{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T16:32:51Z","timestamp":1723393971526},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Clustering techniques such as k-means and hierarchical clustering are commonly used to analyze DNA microarray derived gene expression data. However, the interactions between processes underlying the cell activity suggest that the complexity of the microarray data structure may not be fully represented with discrete clustering methods.<\/jats:p>\n               <jats:p>Results: A newly developed software tool called MILVA (microarray latent visualization and analysis) is presented here to investigate microarray data without separating gene expression profiles into discrete classes. The underpinning of the MILVA software is the two-dimensional topographic representation of multidimensional microarray data. On this basis, the interactive MILVA functions allow a continuous exploration of microarray data driven by the direct supervision of the biologist in detecting activity patterns of co-regulated genes.<\/jats:p>\n               <jats:p>Availability: The MILVA software is freely available. The software and the related documentation can be downloaded from . User \u2018surrey\u2019 as username and \u20183245\u2019 as password to login. The software is currently available for Windows platform only.<\/jats:p>\n               <jats:p>Contact: \u00a0d.lowe@aston.ac.uk<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti676","type":"journal-article","created":{"date-parts":[[2005,9,14]],"date-time":"2005-09-14T03:13:12Z","timestamp":1126667592000},"page":"4192-4193","source":"Crossref","is-referenced-by-count":5,"title":["MILVA: An interactive tool for the exploration of multidimensional microarray data"],"prefix":"10.1093","volume":"21","author":[{"given":"Davide","family":"D'Alimonte","sequence":"first","affiliation":[{"name":"Neural Computing Research Group, Aston University 1 \u00a0 1 \u00a0 \u00a0 Aston Triangle, Birmingham B4 7ET, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Lowe","sequence":"additional","affiliation":[{"name":"Neural Computing Research Group, Aston University 1 \u00a0 1 \u00a0 \u00a0 Aston Triangle, Birmingham B4 7ET, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian T.","family":"Nabney","sequence":"additional","affiliation":[{"name":"Neural Computing Research Group, Aston University 1 \u00a0 1 \u00a0 \u00a0 Aston Triangle, Birmingham B4 7ET, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilis","family":"Mersinias","sequence":"additional","affiliation":[{"name":"School of Biomedical and Molecular Sciences, University of Surrey 2 \u00a0 2 \u00a0 \u00a0 Guildford, Surrey GU2 7XH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin P.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Biomedical and Molecular Sciences, University of Surrey 2 \u00a0 2 \u00a0 \u00a0 Guildford, Surrey GU2 7XH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,9,13]]},"reference":[{"key":"2023061007205722200_b1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1162\/089976698300017953","article-title":"GTM: the generative topographic mapping","volume":"10","author":"Bishop","year":"1997","journal-title":"Neural Comput."},{"key":"2023061007205722200_b2","first-page":"80","article-title":"Latent representation of gene expression dynamics","author":"D'Alimonte","year":"2005"},{"key":"2023061007205722200_b3","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-97610-0","volume-title":"Self-Organizing Maps","author":"Kohonen","year":"1995"},{"key":"2023061007205722200_b4","first-page":"543","article-title":"Neuroscale: novel topographic feature extraction using RBF networks","volume-title":"Advances in Neural Information Processing Systems","author":"Lowe","year":"1997"},{"key":"2023061007205722200_b5","volume-title":"Netlab: Algorithms for Pattern Recognition","author":"Nabney","year":"2001"},{"key":"2023061007205722200_b6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1109\/T-C.1969.222678","article-title":"A non-linear mapping for data structure analysis","volume":"C-18","author":"Sammon","year":"1969","journal-title":"IEEE Trans. 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