{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T10:20:53Z","timestamp":1695637253934},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Viruses and developers of anti-inflammatory therapies share a common interest in proteins that manipulate the immune response. Large double-stranded DNA viruses acquire host proteins to evade host defense mechanisms. Hence, viral pirated proteins may have a therapeutic potential. Although dozens of viral piracy events have already been identified, we hypothesized that sequence divergence impedes the discovery of many others.<\/jats:p>\n               <jats:p>Results: We developed a method to assess the number of viral\/human homologs and discovered that at least 917 highly diverged homologs are hidden in low-similarity alignment hits that are usually ignored. However, these low-similarity homologs are masked by many false alignment hits. We therefore applied a filtering method to increase the proportion of viral\/human homologous proteins. The homologous proteins we found may facilitate functional annotation of viral and human proteins. Furthermore, some of these proteins play a key role in immune modulation and are therefore therapeutic protein candidates.<\/jats:p>\n               <jats:p>Contact: \u00a0kliger@compugen.co.il<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti706","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T00:33:48Z","timestamp":1128645228000},"page":"4216-4222","source":"Crossref","is-referenced-by-count":5,"title":["Discovering hidden viral piracy"],"prefix":"10.1093","volume":"21","author":[{"given":"Eddo","family":"Kim","sequence":"first","affiliation":[]},{"given":"Yossef","family":"Kliger","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2005,10,6]]},"reference":[{"key":"2023061009524964100_b1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0092-8674(92)90274-G","article-title":"A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection","volume":"71","author":"Alcami","year":"1992","journal-title":"Cell"},{"key":"2023061009524964100_b2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0147-9571(96)00013-6","article-title":"Soluble interferon-gamma receptors encoded by poxviruses","volume":"19","author":"Alcami","year":"1996","journal-title":"Comp. 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