{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:49:45Z","timestamp":1772142585238,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Coordinate regulation of gene expression can provide information on gene function. To begin a large-scale analysis of Dictyostelium gene function, we clustered genes based on their expression in wild-type and mutant strains and analyzed their functions.<\/jats:p>\n               <jats:p>Results: We found 17 modes of wild-type gene expression and refined them into 57 submodes considering mutant data. Annotation analyses revealed correlations between co-expression and function and an unexpected correlation between expression and function of genes involved in various aspects of chemotaxis. Co-regulation of chemotaxis genes was also found in published data from neutrophils. To test the predictive power of the analysis, we examined the phenotypes of mutations in seven co-regulated genes that had no published role in chemotaxis. Six mutants exhibited chemotaxis defects, supporting the idea that function can be inferred from co-expression. The clustering and annotation analyses provide a public resource for Dictyostelium functional genomics.<\/jats:p>\n               <jats:p>Supplementary information: \u00a0<\/jats:p>\n               <jats:p>Contact: \u00a0gadi@bcm.tmc.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti726","type":"journal-article","created":{"date-parts":[[2005,10,19]],"date-time":"2005-10-19T03:38:37Z","timestamp":1129693117000},"page":"4371-4377","source":"Crossref","is-referenced-by-count":23,"title":["Microarray phenotyping in <i>Dictyostelium<\/i> reveals a regulon of chemotaxis genes"],"prefix":"10.1093","volume":"21","author":[{"given":"Ezgi O.","family":"Booth","sequence":"first","affiliation":[{"name":"Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine 1 \u00a0 1 \u00a0 \u00a0 Houston, TX 77030, USA"},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine 2 \u00a0 2 \u00a0 \u00a0 Houston, TX 77030, USA"}]},{"given":"Nancy Van","family":"Driessche","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine 2 \u00a0 2 \u00a0 \u00a0 Houston, TX 77030, USA"}]},{"given":"Olga","family":"Zhuchenko","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Baylor College of Medicine 3 \u00a0 3 \u00a0 \u00a0 Houston, TX 77030, USA"}]},{"given":"Adam","family":"Kuspa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine 2 \u00a0 2 \u00a0 \u00a0 Houston, TX 77030, USA"},{"name":"Department of Biochemistry and Molecular Biology, Baylor College of Medicine 3 \u00a0 3 \u00a0 \u00a0 Houston, TX 77030, USA"}]},{"given":"Gad","family":"Shaulsky","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine 2 \u00a0 2 \u00a0 \u00a0 Houston, TX 77030, USA"},{"name":"Graduate Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine 1 \u00a0 1 \u00a0 \u00a0 Houston, TX 77030, USA"}]}],"member":"286","published-online":{"date-parts":[[2005,10,18]]},"reference":[{"key":"2023061007215175700_b1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.cellbio.15.1.469","article-title":"Integration of signaling networks that regulate Dictyostelium differentiation","volume":"15","author":"Aubry","year":"1999","journal-title":"Ann. 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