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The algorithm is designed for use when little or no replication of array hybridizations is available.<\/jats:p><jats:p>Availability: ISER is written in R language, and its code and on-line version are freely available at<\/jats:p><jats:p>Contact: \u00a0menossi@unicamp.br<\/jats:p><jats:p>Supplementary information: \u00a0<\/jats:p>","DOI":"10.1093\/bioinformatics\/bti729","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T00:12:37Z","timestamp":1130371957000},"page":"4427-4429","source":"Crossref","is-referenced-by-count":5,"title":["ISER: selection of differentially expressed genes from DNA array data by non-linear data transformations and local fitting"],"prefix":"10.1093","volume":"21","author":[{"given":"R. D.","family":"Drummond","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Genoma Funcional\u2014Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas 1 \u00a0 1 \u00a0 \u00a0 Campinas 13083-875, PO Box 6010, Brazil"},{"name":"Departmento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas 3 \u00a0 3 \u00a0 \u00a0 Campinas 13083971, Brazil"}]},{"given":"A.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Departmento de Estat\u00edstica, Instituto de Matem\u00e1tica, Estat\u00edstica e Computa\u00e7\u00e3o Cient\u00edfica, Universidade Estadual de Campinas 2 \u00a0 2 \u00a0 \u00a0 Campinas 13083-859, Brazil"}]},{"given":"C. S.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Genoma Funcional\u2014Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas 1 \u00a0 1 \u00a0 \u00a0 Campinas 13083-875, PO Box 6010, Brazil"}]},{"given":"M.","family":"Menossi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Genoma Funcional\u2014Centro de Biologia Molecular e Engenharia Gen\u00e9tica, Universidade Estadual de Campinas 1 \u00a0 1 \u00a0 \u00a0 Campinas 13083-875, PO Box 6010, Brazil"},{"name":"Departmento de Gen\u00e9tica e Evolu\u00e7\u00e3o, Instituto de Biologia, Universidade Estadual de Campinas 3 \u00a0 3 \u00a0 \u00a0 Campinas 13083971, Brazil"}]}],"member":"286","published-online":{"date-parts":[[2005,10,25]]},"reference":[{"key":"2023061007325430900_b1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box","year":"1964","journal-title":"J. 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